[en] This study aimed to evaluate the performance of the microPET FOCUS 120 for 124I in terms of counting rate capability and image quality using the NEMA NU 4-2008 methodology. Scanner sensitivity was measured for 124I for comparison and reached 75 cps/kBq, respectively, with the usual 350-650 keV energy window (EW) and 6 ns time window (TW). The noise equivalent count rate (NECR) index was defined as: NECR = RT2/(RP+RGP) (T = true, P = prompt, GP = γ-prompt). A rat phantom maximum NECR of 48 kcps was obtained for the 250-590 keV EW with 6 ns TW. An almost identical maximum NECR of 43 kcps was recorded for 350-590 and 350-650 keV EW and 6 ns TW. The 2 ns TW reduced the sensitivity and NECR by 40-50% for all EW. The mouse phantom NECR study was limited because of the maximum available activity concentration of 124I. The 250-590 keV EW showed the largest scatter and γ-prompt plus scatter fractions with 25.7% and 43%, respectively, for the rat phantom and 12.2% and 27% for the mouse phantom. With the 350-590 keV EW, these fractions decreased to 20% and 33.5% for the rat phantom and to 10% and 21% for the mouse phantom. The image quality was investigated with the NEMA NU 4-2008 dedicated phantom for four (two analytic and two iterative) 2D or 3D reconstruction methods. The lowest spillover ratios (SOR) for the phantom non-emitting regions were obtained for the 350-590 and 350-650 keV EWs. Recovery coefficients (RC) of the hot rods were the highest for the 350-590 keV EW except for the 1 mm rod. Scatter correction led to a large decrease in RC. The combination of the 350-590 keV EW with 6 ns TW appeared to be a good compromise between counting rate capability and image quality for the FOCUS 120, especially when maximum a posteriori reconstruction was used without scatter correction. Moreover this combination enabled the best quantification with an error as low as 0.36%.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Taleb, Dounia ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale
Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron
Seret, Alain ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale
Warnock, Geoffrey ; Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Anizan, Nadège
Language :
English
Title :
Performance Measurements of the microPET FOCUS 120 for Iodine-124 Imaging
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Bibliography
M. E. A. O'Connell, M. A. Flower, P. J. Hinton, C. L. Harmer, and V. R. McCready, "Radiation dose assessment in radioiodine therapy. Dose-response relationships in differentiated thyroid carcinoma using quantitative scanning and PET," Radiother. Oncol., vol. 28, pp. 16-26, Jul. 1993.
I. Verel et al., "Long-lived positron emitters and for scouting of therapeutic radioimmunoconjugates with PET," Cancer Biother. Ra-diopharm., vol. 18, no. 4, pp. 655-661, Aug. 2003.
M. Lubberink, A. van Schie, H. de Jong, G. van Dongen, and G. Teule, "Acquisition settings for PET of administered simultaneously with therapeutic amounts of, " J. Nucl. Med., vol. 47, no. 8, pp. 1375-1381, Aug. 2006.
H. Herzog, L. Tellmann, S. M. Qaim, S. Spellerberg, A. Schmid, and H. H. Coenen, "PET quantitation and imaging of the non pure-emitting iodine isotope, " Appl. Radiat. Isot., vol. 56, no. 5, pp. 673-679, May 2002.
J. Disselhorst et al., "Image quality assessment for several positron emitters using the NEMA NU 4 2008 standards in the Inveon small-animal PET scanner," J. Nucl. Med., vol. 51, no. 4, pp. 610-617, Mar. 2010.
R. Laforest, D. Longford, S. Siegel, D. F. Newport, and J. Yap, "Performance evaluation of the microPET®\FOCUS-F120," IEEE Trans. Nucl. Sci., vol. 54, no. 1, pp. 2965-2969, Feb. 2007.
J. S. Kim et al., "Performance measurement of the microPET focus 120 scanner," J. Nucl. Med., vol. 48, no. 9, pp. 1527-1535, Sep. 2007.
M. A. Bahri, A. Plenevaux, G. Warnock, A. Luxen, and A. Seret, "NEMA NU4-2008 image quality performance report for the mi-croPET focus 120 and for various transmission and reconstruction methods," J. Nucl. Med., vol. 50, no. 10, pp. 1730-1738, Sep. 2009.
M. Defrise, P. E. Kinahan, D. W. Townsend, C. Michel, M. Sibomana, and D. F. Newport, "Exact and approximate rebinning algorithms for 3-D PET data," IEEE Trans. Med. Imag., vol. 16, no. 2, pp. 145-158, Apr. 1997.
D. L. Bailey, T. Jones, and T. J. Spinks, "A method for measuring the absolute sensitivity of positron emission tomographic scanners," Eur. J. Nucl. Med., vol. 18, no. 6, pp. 374-379, Jun. 1991.
M. E. Daube-Witherspoon and G. Muehllehner, "Treatment of axial data in three-dimensional PET," J. Nucl. Med., vol. 28, no. 11, pp. 1717-1724, Nov. 1987.
C. C. Watson, M. E. Casey, L. Eriksson, T. Mulnix, D. Adams, and B. Bendriem, "NEMA NU 2 performance tests for scanners with intrinsic radioactivity," J. Nucl. Med., vol. 45, no. 5, pp. 822-826, May 2004.
C. C. Constantinescu and J. Mukherjee, "Performance evaluation of an Inveon PET preclinical scanner," Phys. Med. Biol., vol. 54, pp. 2885-2899, May 2009.
M. Lubberink, H. Schneider, M. Bergström, and H. Lundqvist, "Quantitative imaging and correction for cascade gamma radiation of with 2D and 3D PET," Phys. Med. Biol., vol. 47, pp. 3519-3534, Oct. 2002.
R. A. Gregory, C. A. Hooker, M. Partridge, and G. D. Flux, "Optimization and assessment of quantitative imaging on a philips gemini dual GS PET/CT system," Eur. J. Nucl. Med. Mol. Imag., vol. 36, no. 7, pp. 1037-1048, Jul. 2009.
S. C. Strother, M. E. Casey, and E. J. Hoffman, "Measuring PET scanner sensitivity relating count rates to image signal-to-noise ratios using noise equivalent counts," IEEE Trans. Nucl. Sci., vol. 37, no. 2, pp. 783-788, Apr. 1990.
G. Brix et al., "Performance evaluation of a whole-body PET scanner using the NEMA protocol," J. Nucl. Med., vol. 38, no. 10, pp. 1614-1623, Oct. 1997.
H. M. Hudson and R. S. Larkin, "Accelerated image reconstruction using ordered subsets of projection data," IEEE Trans. Med. Imag., vol. 13, no. 4, pp. 601-609, Dec. 1994.
P. E. Kinahan and J. G. Rogers, "Analytic three-dimensional image reconstruction using all detected events," IEEE Trans. Nucl. Sci., vol. 36, no. 1, pp. 964-968, Feb. 1989.
J. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Far-quhar, "High-resolution 3D bayesian image reconstruction using the microPET small-animal scanner," Phys. Med. Biol., vol. 43, pp. 1001-1013, Apr. 1998.
C. Watson, D. Newport, and M. E. Casey, "A single scatter simulation technique for scatter correction in 3D PET," in Three-Dimensionnal Image Reconstruction in Radiology and Nuclear Medecine, P. Grangeat and J.-L. Amans, Eds. Dordrecht, The Netherlands: Kluwer, 1996, pp. 255-268.
R. Laforest and X. Liu, "Quantitative small animal PET imaging with nonconventional nuclides," Nucl. Med. Biol., vol. 36, pp. 551-559, 2009.
M. R. Palmer, X. Zhu, and J. A. Parker, "Modeling and simulation of positron range effects for high resolution PET imaging," IEEE Trans. Nucl. Sci, vol. 52, no. 5, pp. 1391-1395, Oct. 2005.
S. Vandenberghe, "Three-dimensional positron emission tomography imaging with 124I and 86Y," Nucl. Med. Com., vol. 27, no. 3, pp. 237-245, Mar. 2006.
Y. Yongfeng and S. R. Cherry, "Observations regarding scatter fraction and NEC measurements for small animal PET," IEEE Trans. Nucl. Sci., vol. 53, no. 1, pp. 127-132, Feb. 2006.
S. Surti, R. Scheuermann, and J. S. Karp, "Correction technique for cascade gammas in I-124 imaging on a fully-3D, time-of-flight PET scanner," IEEE Trans. Nucl. Sci., vol. 56, no. 3, pp. 653-660, Jun. 2009.
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