Performance Measurements of the microPET FOCUS 120 for Iodine-124 Imaging

Taleb, Dounia; Bahri, Mohamed Ali; Seret, Alain; Warnock, Geoffrey; Salmon, Eric; Luxen, André; Plenevaux, Alain; Anizan, Nadège

doi:10.1109/TNS.2012.2205402

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Performance Measurements of the microPET FOCUS 120 for Iodine-124 Imaging

Taleb, Dounia; Bahri, Mohamed Ali; Seret, Alain et al.

2012 • In IEEE Transactions on Nuclear Science, 59 (5), p. 1868-1878

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10.1109/TNS.2012.2205402

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Keywords :

microPET; Performance tests; Iodine-124

Abstract :

[en] This study aimed to evaluate the performance of the microPET FOCUS 120 for 124I in terms of counting rate capability and image quality using the NEMA NU 4-2008 methodology. Scanner sensitivity was measured for 124I for comparison and reached 75 cps/kBq, respectively, with the usual 350-650 keV energy window (EW) and 6 ns time window (TW). The noise equivalent count rate (NECR) index was defined as: NECR = RT2/(RP+RGP) (T = true, P = prompt, GP = γ-prompt). A rat phantom maximum NECR of 48 kcps was obtained for the 250-590 keV EW with 6 ns TW. An almost identical maximum NECR of 43 kcps was recorded for 350-590 and 350-650 keV EW and 6 ns TW. The 2 ns TW reduced the sensitivity and NECR by 40-50% for all EW. The mouse phantom NECR study was limited because of the maximum available activity concentration of 124I. The 250-590 keV EW showed the largest scatter and γ-prompt plus scatter fractions with 25.7% and 43%, respectively, for the rat phantom and 12.2% and 27% for the mouse phantom. With the 350-590 keV EW, these fractions decreased to 20% and 33.5% for the rat phantom and to 10% and 21% for the mouse phantom. The image quality was investigated with the NEMA NU 4-2008 dedicated phantom for four (two analytic and two iterative) 2D or 3D reconstruction methods. The lowest spillover ratios (SOR) for the phantom non-emitting regions were obtained for the 350-590 and 350-650 keV EWs. Recovery coefficients (RC) of the hot rods were the highest for the 350-590 keV EW except for the 1 mm rod. Scatter correction led to a large decrease in RC. The combination of the 350-590 keV EW with 6 ns TW appeared to be a good compromise between counting rate capability and image quality for the FOCUS 120, especially when maximum a posteriori reconstruction was used without scatter correction. Moreover this combination enabled the best quantification with an error as low as 0.36%.

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Taleb, Dounia ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale

Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron

Seret, Alain ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale

Warnock, Geoffrey ; Université de Liège - ULiège > Centre de recherches du cyclotron

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Anizan, Nadège

Language :

English

Title :

Performance Measurements of the microPET FOCUS 120 for Iodine-124 Imaging

Publication date :

17 September 2012

Journal title :

IEEE Transactions on Nuclear Science

ISSN :

0018-9499

Publisher :

IEEE, New York, United States - New York

Volume :

Issue :

Pages :

1868-1878

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6304946

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since 09 February 2013

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