Article (Scientific journals)
Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats.
Roosens, Bram; Bala, Gezim; Gillis, Kris et al.
2013In Cardiovascular Ultrasound, 11 (1), p. 4
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Abstract :
[en] ABSTRACT: BACKGROUND: Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifications in a rat model of reversible renal failure with CAVD, compared to histology. METHODS: 28 male Wistar rats were prospectively followed during 21 weeks. Group 1 (N=14) was fed with a 0.5% adenine diet for 9 weeks to induce renal failure and CAVD. Group 2 (N=14) received a standard diet. At week 9, six animals of each group were killed. The remaining animals of group 1 (N=8) and group 2 (N=8) were kept on a standard diet for an additional 12 weeks. cIB of the aortic valve was calculated at baseline, 9 and 21 weeks, followed by measurement of the calcified area (Ca Area) on histology. RESULTS: At week 9, cIB values and Ca Area of the aortic valve were significantly increased in the adenine-fed rats compared to baseline and controls. After 12 weeks of adenine diet cessation, cIB values and Ca Area of group 1 decreased compared to week 9, while there was no longer a significant difference compared to age-matched controls of group 2. CONCLUSIONS: cIB is a non-invasive tool allowing quantitative monitoring of CAVD progression and regression in a rat model of reversible renal failure, as validated by comparison with histology. This technique might become useful for assessing CAVD during targeted therapy.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Roosens, Bram
Bala, Gezim
Gillis, Kris
Remory, Isabel
Droogmans, Steven
Somja, Joan ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Delvenne, Eléonore ;  Université de Liège - ULiège > 3e an. méd.
Nayer, Joeri
Schiettecatte, Johan
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Camp, Guy
Cosyns, Bernard
More authors (3 more) Less
Language :
English
Title :
Echocardiographic integrated backscatter for detecting progression and regression of aortic valve calcifications in rats.
Publication date :
2013
Journal title :
Cardiovascular Ultrasound
eISSN :
1476-7120
Publisher :
BioMed Central
Volume :
11
Issue :
1
Pages :
4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 February 2013

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