Polyester nanoparticles presenting mannose residues : toward the development of new vaccine delivery systems combining biodegradability and targeting properties
[en] We report the synthesis of fully biodegradable polymeric nanoparticles presenting mannose residues at their surface and their interaction with lectins. A simple and versatile method was used to reach the surface functionalization of poly(d,l-lactic acid) (PLA) nanoparticles by mannose moieties: It consists in using an amphiphilic mannosylated poly(ethylene oxide)-b-poly(-caprolactone) (PEO-b-PCL) diblock copolymer as a bioresorbable surface modifier in a simple nanoprecipitation-evaporation procedure. The size and zeta potential of the nanoparticles were found to depend on the molar copolymer/PLA ratio, demonstrating the influence of the copolymer on the formation of the nanoparticles. The bioavailability of the mannose residues as specific recognition sites on the nanoparticle surface could be demonstrated by a modified enzyme-linked lectin assay (ELLA) using biotin-labeled lectins which interact specifically with α-d-mannopyrannoside derivatives. Besides specific interaction by lectin−mannose complex formation, nonspecific adsorption of the proteins on the nanoparticle surface was observed. These results were fully supported by isothermal titration calorimetry experiments which suggested that the balance between specific and nonspecific interactions can be controlled by the amount of glycosylated polymer used for the preparation of the nanoparticles. Such nanoparticles are expected to be specifically recognized by mannose receptors, which are highly expressed in cells of the immune system. The targeting properties of these carrier systems combined with their potential adjuvant effects due to their size in the range of 200−300 nm make them attractive candidates as vaccine delivery systems.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Rieger, Jutta ; Université de Liège - ULiège et Grenoble (France) > Department of Chemistry (Liège) > Center for Education and Research on Macromolecules (CERM, Liège) et CERMAV (Grenoble)
Freichels, Hélène ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Imberty, Anne; Grenoble, France > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
Putaux, Jean-Luc; Grenoble, France > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
Delair, Thierry; Université Claude Bernard Lyon 1, Villeurbanne, France > Laboratoire des Mateériaux Polymères et Biomatériaux
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Auzely-Velty, Rachel; Grenoble, France > Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS)
Language :
English
Title :
Polyester nanoparticles presenting mannose residues : toward the development of new vaccine delivery systems combining biodegradability and targeting properties
Publication date :
09 March 2009
Journal title :
Biomacromolecules
ISSN :
1525-7797
eISSN :
1526-4602
Publisher :
American Chemical Society, Washington, United States - District of Columbia
The European Community's Sixth Framework program in the frame of a Marie Curie fellowship
Funders :
BELSPO - Service Public Fédéral de Programmation Politique scientifique Région wallonne EU - European Union CNRS - Centre National de la Recherche Scientifique
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Bibliography
Gu, F. X.; Karnik, R.; Wang, A. Z.; Alexis, F.; Levy-Nissenbaum, E.; Hong, S.; Langer, R. S.; Farokhzad, O. C. Nanotoday 2007, 2, 14-21.
Rieger, J.; Jérôme, C.; Jérôme, R.; Auzély-Velty, R. Polymeric Nanomaterials: Synthesis, Functionalization and Applications in Diagnosis and Therapy In Nanotechnologies for the Life Sciences: Nanomaterials for Medical Diagnosis and Therapy; Challa, S. S. R., Kumar, Eds.; Wiley: Weinheim, Germany, 2007; Vol. 10, pp 342-408.
Allemann, E.; Gurny, R.; Doelker, E. Eur. J. Pharm. Biopharm. 1993, 39, 173-191.
Jagur-Grodzinski, J. React. Funct. Polym. 1999, 39, 99-138.
Gref, R.; Minamitake, Y.; Peracchia, M. T.; Trubetskoy, V.; Torchilin, V.; Langer, R. Science 1994, 263, 1600-1603.
Stolnik, S.; Dunn, S. E.; Garnett, M. C.; Davies, M. C.; Coombes, A. G. A.; Ilium, L.; Davis, S. S.; Taylor, D. C.; Irving, M. P.; Purkiss, S. C. Pharm. Res. 1994, 11, 1800-1808.
Verracchia, T.; Spenlehauer, G.; Bazile, D. V.; Murry-Brelier, A.; Archimbaud, Y.; Veillard, M. J. Controlled Release 1995, 36, 49-61.
Davis, S. S.; Ilium, L.; Stolnik, S. Curr. Opin. Colloid Interface Sci. 1996, 1, 660-666.
Lee, J. H.; Lee, H. B.; Andrade, J. D. Prog. Polym. Sci. 1995, 20, 1043-1079.
Riley, T.; Govender, T.; Stolnik, S.; Xiong, C. D.; Garnett, M. C.; Ilium, L.; Davis, S. S. Colloid Surf.. B 1999, 16, 147-159.
Bazile, D.; Prud'Homme, C.; Bassoullet, M.-T.; Marland, M.; Spenlehauer, G.; Veillard, M. J. Pharm. Sci. 1995, 84, 493-498.
Lemarchand, C.; Gref, R.; Couvreur, P. Eur.JPharm.Biopharm. 2004, 58, 327-341.
Cheng, J.; Teply, B. A.; Sherifi, I.; Sung, J.; Luther, G.; Gu, F. X.; Levy-Nissenbaum, E.; Radovic-Morgno, A. F.; Langer, R.; Farokhzad, O. C. Biomaterials 2007, 28, 869-876.
Cho, C. S.; Jeong, Y. I.; Ishihara, T.; Takei, R.; Park, J. U.; Park, K. H.; Maruyama, A.; Akaike, T. Biomaterials 1997, 18, 323-326.
Maruyama, A.; Ishihara, T.; Kim, J. S.; Kim, S. W.; Akaike, T. Bioconiugate Chem. 1997, 8, 735-742.
Cho, C. S.; Cho, K. Y.; Park, I. K.; Kim, S. H.; Sasagawa, T.; Uchiyama, M. J. Controlled Release 2001, 77, 7-15.
Cho, C. S.; Kobayashi, A.; Takei, R.; Ishihara, T.; Maruyama, A.; Akaike, T. Biomaterials 2001, 22, 45-51.
White, K. L.; Rades, T.; Furneaux, R. H.; Tyler, P. C.; Hook, S. J. Pharm. Pharmacol. 2006, 58, 729-37.
Irache, J. M.; Salman, H. H; Gamazo, C.; Espuelas, S. Expert Ovin. Drug Delivery 2008, 5, 703-724.
Warren, H. S.; Leclerc, C. Adjuvants. In Encyclopedia in Immunology, 2nd ed.; Delves, P. J., Roitt, I.M., Eds.; Academic Press: San Diego, 1998; Vol. 1, pp 36-39.
Kreuter, J.; Speiser, P. P. Infect. Immun. 1976, 204-210.
Fessi, H.; Puisieux, F.; Devissaguet, J.Ph.; Ammoury, N.; Benita, S. Int. J. Pharm. 1989, 55, R1-R4.
Stolnik, S.; Davies, M. C.; Ilium, L.; Davis, S. S.; Bousta, M.; Vert, M. J. Controlled Release 1994, 30, 57-67.
Coombes, A. G. A.; Tasker, S.; Linblad, M.; Holmgren, K.; Hoste, K.; Toncheva, V.; Schacht, E.; Davies, M. C.; Ilium, L.; Davis, S. S. Biomaterials 1994, 15, 673-680.
Dubochet, J.; Adrian, M.; Chang, J. J.; Homo, J.-C.; Lepault, J.; McDowall, A. W.; Schultz, P. Ouart. Rev. Phys. 1988, 21, 129-228.
Harris, J. R. Negative Staining and Cryoelectron Microscopy: The Thin Films Techniques; Bios Scientific Publishers: Oxford, U.K., 1997.
Negrete-Herrera, N.; Letoffe, J. M.; Putaux, J. L.; David, L.; Bourgeat- Lami, E. Langmuir 2004, 20, 1564-1571.
Lameignere, E.; Malinovská, L.; Sláviková, M.; Duchaud, E.; Mitchell, E. P.; Varrot, A.; Šedo, O.; Imberty, A.; Wimmerová, M. Biochem. J. 2008, 81, 12846-12858.
Cade, D.; Ramus, E.; Rinaudo, M.; Auzély-Velty, R.; Delair, T.; Hamaide, T. Biomacromolecules 2004, 5, 922-927.
Gautier, S.; D'Aloia, V.; Halleux, O.; Mazza, M.; Lecomte, P.; Jérôme, R. J. Biomater. Sci. Polym. Ed. 2003, 14, 63-85.
Vila, A.; Gill, H.; McCallion, O.; Alonso, M. J. J. Controlled Release 2004, 98, 231-244.
Dam, T. K.; Brewer, C. F. Chem. Rev. 2002, 102, 387-430.
Arai, T.; Norde, W. Colloids Surf. 1990, 51, 1-15.
Cai, P.; Huang, Q.; Jiang, D.; Rong, X.; Liang, W. Colloid Surf., B 2006, 49, 49-54.
Love, J. C.; Estroff, L. A.; Kriebel, J. K.; Nuzzo, R. G.; Whitesides, G. M. Chem. Rev. 2005, 105, 1103-1169.
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