Neirinckx, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie
Marquet, Alice ; Université de Liège - ULiège > GIGA - Neurosciences
Poulet, Christophe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Laudet, Emerence
Coste, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Manguette, Jérôme ; Université de Liège - ULiège > 2e an. master sc. bioméd., fin. approf.
Rogister, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Wislet, Sabine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Adult Bone Marrow Neural Crest and Mesenchymal Stem Cells : Which Role in Therapy of Neurological Pathologies ?
Publication date :
28 January 2013
Event name :
GIGA Day 2013
Event date :
28 janvier 2013
Commentary :
Neurodegenerative and acute neurological pathologies represent a critical issue in clinical research, since no complete recovery of the central nervous system (CNS) functionality can be achieved with current therapeutic means. Besides, adult neurogenesis does not seem to be sufficient to enable neuronal regeneration in cases of traumatic, ischemic or degenerative damages of the CNS. Therefore, other strategies have to be considered in order to restore injured system. Stem cell-based replacement therapies have already been proposed and studied worldwide in a perspective of neurological diseases management. Several preclinical studies have been performed using bone marrow stromal stem cells (BMSC), but without isolating the different types of cells they include. In this study, we will investigate both the benefits and drawbacks of adult bone marrow neural crest stem cells (NCSC) compared to mesenchymal stem cells (MSC) in this kind of therapies, in order to verify the suitability of each type of cells in a clinical perspective.
