Article (Scientific journals)
HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.
Redel, Laetitia; Le Douce, Valentin; Cherrier, Thomas et al.
2010In Journal of Leukocyte Biology, 87 (4), p. 575-88
Peer Reviewed verified by ORBi
 

Files


Full Text
HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.pdf
Publisher postprint (1.62 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes/immunology/virology; HIV Infections/drug therapy/immunology; HIV-1/physiology; Humans; Macrophages/immunology/virology; Monocytes/immunology/virology; Virus Activation/drug effects/immunology; Virus Latency/drug effects/immunology
Abstract :
[en] The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. In this review, we focus on the establishment and maintenance of HIV-1 latency in the two major targets for HIV-1: the CD4+ T cells and the monocyte-macrophage lineage. Understanding the cell-type molecular mechanisms of establishment, maintenance, and reactivation of HIV-1 latency in these reservoirs is crucial for efficient therapeutic intervention. A complete viral eradication, the holy graal for clinicians, might be achieved by strategic interventions targeting latently and productively infected cells. We suggest that new approaches, such as the combination of different kinds of proviral activators, may help to reduce dramatically the size of latent HIV-1 reservoirs in patients on HAART.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Redel, Laetitia
Le Douce, Valentin
Cherrier, Thomas ;  Université de Liège - ULiège > GIGA-Research
Marban, Celine
Janossy, Andrea
Aunis, Dominique
Van Lint, Carine
Rohr, Olivier
Schwartz, Christian
Language :
English
Title :
HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.
Publication date :
2010
Journal title :
Journal of Leukocyte Biology
ISSN :
0741-5400
Publisher :
Federation of American Societies for Experimental Biology, United States - New York
Volume :
87
Issue :
4
Pages :
575-88
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 January 2013

Statistics


Number of views
190 (1 by ULiège)
Number of downloads
708 (0 by ULiège)

Scopus citations®
 
50
Scopus citations®
without self-citations
41
OpenCitations
 
49

Bibliography


Similar publications



Contact ORBi