Reference : Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/140679
Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.
English
Cherrier, Thomas mailto [Université de Liège - ULiège > GIGA-Research > > >]
Elias, Mikael [> >]
Jeudy, Alicia [> >]
Gotthard, Guillaume [> >]
Le Douce, Valentin [> >]
Hallay, Houda [> >]
Masson, Patrick [> >]
Janossy, Andrea [> >]
Candolfi, Ermanno [> >]
Rohr, Olivier [> >]
Chabriere, Eric [> >]
Schwartz, Christian [> >]
2011
Virology Journal
8
352
Yes (verified by ORBi)
International
1743-422X
England
[en] Cells, Cultured ; HIV-1/immunology/physiology ; Host-Pathogen Interactions ; Humans ; Leukocytes, Mononuclear/immunology/virology ; Macrophages/immunology/virology ; Phosphate-Binding Proteins/immunology ; T-Lymphocytes/immunology/virology ; Transcription, Genetic ; Virus Replication
[en] The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in naive and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.
http://hdl.handle.net/2268/140679
10.1186/1743-422X-8-352

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