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Keywords :
Blood Glucose/metabolism; Diabetes Mellitus/blood/drug therapy/physiopathology; Double-Blind Method; Female; Fluoxetine/adverse effects/therapeutic use; Glucose Tolerance Test; Hemoglobin A, Glycosylated/analysis; Humans; Hyperglycemia/blood/physiopathology; Insulin/blood; Male; Middle Aged; Obesity/blood/drug therapy/physiopathology; Placebos; Weight Loss
Abstract :
[en] A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a similar calorie-restricted diet was prescribed to all patients. Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved. Drop-out rate was not significantly different for both groups of patients.
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