Article (Scientific journals)
The relationship of human atrial cellular electrophysiology to clinical function and ultrastructure.
Mary-Rabine, L; Albert, Adelin; Pham, T.D. et al.
1983In Circulation Research, 52 (2), p. 188-99
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Keywords :
Adolescent; Adult; Aged; Arrhythmias, Cardiac/physiopathology; Arteriosclerosis/physiopathology; Cardiomegaly/physiopathology; Child; Child, Preschool; Diastole; Electrophysiology; Female; Heart Atria/physiopathology/ultrastructure; Heart Defects, Congenital/physiopathology; Humans; Infant; Male; Membrane Potentials; Middle Aged; Myocardium/ultrastructure; Rheumatic Heart Disease/physiopathology
Abstract :
[en] Although previous studies have described the electrophysiological and ultrastructural characteristics of human cardiac fibers, no attempt has been made as yet to describe quantitatively the relationship between the ultrastructural and cellular electrophysiological derangements occurring with cardiac disease, and their clinical manifestations. In this study, we used standard microelectrode techniques to record the action potential characteristics of human atrial fibers obtained during cardiac surgery and correlated the electrophysiological parameters with clinical and ultrastructural data. Ultrastructure was studied by optical and electron microscopy. We found a multiple linear regression among maximum diastolic potential, atrial size and pressure, P wave duration and ultrastructure changes. Proliferations of Z band material, widening of intercalated discs, and degenerative changes were quantified and correlated with electrophysiological and clinical data. These studies emphasize the relationship between hemodynamic anomalies and resultant changes in both human atrial fiber structure and electrical function. Finally, the likelihood of occurrence of arrhythmias can be predicted using the analytic method described.
Disciplines :
General & internal medicine
Author, co-author :
Mary-Rabine, L
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Pham, T.D.
Hordof, A
Fenoglio, J J Jr
Malm, J R
Rosen, M R
Language :
English
Title :
The relationship of human atrial cellular electrophysiology to clinical function and ultrastructure.
Publication date :
1983
Journal title :
Circulation Research
ISSN :
0009-7330
eISSN :
1524-4571
Publisher :
Lippincott Williams & Wilkins, Baltimore, United States - Maryland
Volume :
52
Issue :
2
Pages :
188-99
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2013

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