Reference : Neuroestrogens Rapidly Regulate Sexual Motivation But Not Performance
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/139400
Neuroestrogens Rapidly Regulate Sexual Motivation But Not Performance
English
Seredynski, Aurore mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Balthazart, Jacques mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Christophe, Virginie [> >]
Ball, Gregory [> >]
Cornil, Charlotte mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2-Jan-2013
Journal of Neuroscience
Society for Neuroscience
33
1
164-174
Yes (verified by ORBi)
International
0270-6474
1529-2401
Washington
DC
[en] Estrogens exert pleiotropic effects on reproductive traits, which include differentiation and activation of reproductive behaviors and the
control of the secretion of gonadotropins. Estrogens also profoundly affect non-reproductive traits, such as cognition and neuroprotection.
These effects are usually attributed to nuclear receptor binding and subsequent regulation of target gene transcription. Estrogens
also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. How these two types of actions that
operate in distinct timescales interact in the control of complex behavioral responses is poorly understood. Here, we show that the central
administration of estradiol rapidly increases the expression of sexual motivation, as assessed by several measures of sexual motivation
produced in response to the visual presentation of a female but not sexual performance in male Japanese quail. This effect is mimicked by
membrane-impermeable analogs of estradiol, indicating that it is initiated at the cell membrane. Conversely, blocking the action of
estrogens or their synthesis by a single intracerebroventricular injection of estrogen receptor antagonists or aromatase inhibitors,
respectively, decreases sexual motivation within minutes without affecting performance. The same steroid has thus evolved complementary
mechanisms to regulate different behavioral components (motivation vs performance) in distinct temporal domains (long- vs
short-term) so that diverse reproductive activities can be properly coordinated to improve reproductive fitness. Given the pleiotropic
effects exerted by estrogens, other responses controlled by these steroids might also depend on a slow genomic regulation of neuronal
plasticity underlying behavioral activation and an acute control of motivation to engage in behavior.
National Institutes of Health - NIH ; Fonds Spéciaux ULg ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/139400
10.1523/JNEUROSCI.2557-12.2013
http://reflexions.ulg.ac.be/oestradiolcaille

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