Modulation of hormonal signaling in the brain by steroid receptor coactivators.

Animals; Gene Expression Regulation; Histone Acetyltransferases; Nuclear Receptor Coactivator 2/genetics/metabolism; Preoptic Area/cytology/metabolism; Receptors, Steroid/genetics/metabolism; Sexual Behavior, Animal/physiology; Signal Transduction/physiology; Steroids/metabolism; Trans-Activators/genetics/metabolism; Transcription Factors/genetics/metabolism

Abstract :

[en] Nuclear receptors, such as estrogen, glucocorticoid or thyroid hormone receptors, have been shown to play a critical role in brain development and physiology. The activity of these receptors is modulated by the interaction with several proteins and, in particular, coactivators are required to enhance their transcriptional activity. The steroid receptor coactivators (SRC-1, -2 and -3) are currently the best characterized coactivators and we review here the current knowledge on the distribution and function of these proteins in the brain. Knock-out models and antisense techniques have demonstrated the requirement for SRC-1 and -2 in the brain, focusing mainly on steroid and thyroid hormone-dependent development and behavior. The precise function of SRC-3 in the brain is currently unknown but its presence throughout the brain suggests an important function. Although the molecular biology of SRCs is relatively well known, the in vivo control of their expression, post-translational modifications and time- and cell-specific interactions with the different nuclear receptors remain elusive. A complete understanding of hormone action on brain and behavior will not be attained until a better knowledge of coactivator physiology is achieved.

Disciplines :

Neurosciences & behavior

Author, co-author :

Charlier, Thierry ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Language :

English

Title :

Modulation of hormonal signaling in the brain by steroid receptor coactivators.

Publication date :

2005

Journal title :

Reviews in the Neurosciences

ISSN :

0334-1763

eISSN :

2191-0200

Publisher :

Freund Publishing House Ltd, London, United Kingdom

Volume :

Issue :

Pages :

339-57

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2009

Statistics

Number of views

99 (3 by ULiège)

Number of downloads

1 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Absil P, Baillien M, Ball GF, Panzica G, Balthazart J. The control of preoptic aromatase activity by afferent inputs in Japanese quail. Brain Res Rev 2001; 37: 38-58.
Acevedo ML, Kraus WL. Mediator and p300/CBP steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor α-dependent transcription with chromatine templates. Mol Cell Biol 2003; 23: 335-348.
Adkins EK, Boop JJ, Koutnik DL, Morris JB, Pnieswski EE. Further evidence that androgen aromatization is essential for the activation of copulation in male quail. Physiol Behav 1980; 24: 441-446.
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997; 277: 965-968.
Apostolakis EM, Ramamurphy M, Zhou D, Onate SA, O'Malley BW. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Mol Endocrinol 2002; 16: 1511-1523.
Arai S, Ogawa K, Yamachika S, Nishihara T, Nishikawa J. Cloning and functional characterization of chicken p160 coactivator family members. Biochim Biophys Acta 2001; 1518: 7-18.
Aste N, Panzica GC, Aimar P, Viglietti-Panzica C, Foidart A, Balthazart J. Implication of testosterone metabolism in the control of the sexually dimorphic nucleus of the quail preoptic area. Brain Res Bull 1993; 31: 601-611.
Aste N, Panzica GC, Viglietti-Panzica C, Harada N, Balthazart J. Distribution and effects of testosterone on aromatase mRNA in the quail forebrain: A non-radioactive in situ hybridization study. J Chem Neuroanat 1998; 14: 103-115.
Auboeuf D, Dowhan DH, Kang YK, Larkin K, Lee JW, Berget SM, O'Malley BW. Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes. Proc Natl Acad Sci USA 2004; 101: 2270-2274
Auger AP, Perrot-Sinal TS, Auger CJ, Tetel MJ, McCarthy MM. Differential expression of nuclear receptor co-activator in neonatal male and female rat brain. Society for Neuroscience, San Diego, 2001, Abstract no. 141-15.
Auger AP, Tetel MJ, McCarthy MM. Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Proc Natl Acad Sci USA 2000; 97: 7551-7555.
Auger CJ, Ball GF. Expression of steroid receptor coactivator-1 (SRC-1) in the brain of two species of songbird. Horm Behav 2002; 41: 455.
Bai W, Rowan BG, Allgood, VE, O'Malley, BW, Weigel, NL. Differential phosphorylation of chicken progesterone receptor in hormone-dependent, ligand-independent activation. J Biol Chem 1997; 272: 10457-10463.
Ball GF, Auger CJ, Bernard DJ, Charlier TD, Sartor JJ, Riters LV, Balthazart J. Seasonal plasticity in the song control system: multiple brain sites of steroid hormone action and the importance of variation in song behavior. Ann NY Acad Sci 2004; 1016: 586-610.
Ball GF, Balthazart J. Neuroendocrine mechanisms regulating reproductive cycles and reproductive behavior in birds. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, Brain and Behavior. San Diego, CA: Academic Press, 2002; 2: 649-798.
Balthazart J, Baillien M, Cornil CA, Ball GF. Preoptic aromatase modulates male sexual behavior: slow and fast mechanisms of action. Physiol Behav 2004; 83: 247-270.
Balthazart J, Ball GF. The Japanese quail as a model system for the investigation of steroid-catecholamine interactions mediating appetitive and consummatory aspects of male sexual behavior. Annu Rev Sex Res 1998; 9: 96-176.
Balthazart J, Foidart A, Hendrick C. The induction by testosterone of aromatase activity in the preoptic area and activation of copulatory behavior. Physiol Behav 1990; 47: 83-94.
Balthazart J, Foidart A, Wilson EM, Ball GF. Immunocytochemical localization of androgen receptors in the male quail brain. J Comp Neurol 1992; 317: 407-420.
Balthazart J, Gahr M, Surlemont C. Distribution of estrogen receptors in the brain of the Japanese quail: an immunocytochemical study. Brain Res 1989; 50: 205-214.
Balthazart J, Surlemont C, Harada N. Aromatase as a cellular marker of testosterone action in the preoptic area. Physiol Behav 1992; 51: 395-409.
Balthazart J, Tlemçani O, Ball GF. Do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? What 25 years of research on the Japanese quail tells us. Horm Behav 1996; 30: 627-661.
Barfield RJ, Chen JJ. Activation of estrous behavior in ovariectomized rats by intracerebral implants of estrabiol benzoate. Endocrinology 1977; 101: 1716-1725.
Beato M, Herrlich P, Schütz G. Steroid hormone receptors: many actors in a search of a plot. Cell 1995; 83: 851-857.
Bernal J. Thyroid hormone and brain development. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, Brain and Behavior. San Diego, CA: Academic Press, 2002; 543-588.
Bernard DJ, Ball GF. Photoperiodic condition modulates the effects of testosterone on song control nuclei volumes in male European starling. Gen Comp Endocrinol 1997; 105: 276-283.
Berthold AA. Transplantation of the testis. Trans by Quiring DP. Bull History Med 1849; 16: 42-46.
Björnström L, Sjöberg M. Mechanism of estrogen receptor signaling: convergence of genomic and non-genomic actions on target genes. Mol Endocrinol 2005; 19: 833-842.
Blanco JCG, Minucci S, Lu J, Yang X-J, Walker KK, Chen H, Evans RM, Nakatan Y, Ozato K. The histone acetylase PCAF is a nuclear receptor coactivator. Gen Dev 1998; 12: 1638-1651.
Bousios S, Karandrea D, Kittas C, Kitraki E. Effects of gender and stress on the regulation of steroid receptor coactivator-1 expression in the rat brain and pituitary. J Steroid Bioch Mol Biol 2001; 78: 401-407.
Chan H, Lin RG, Xie W, Wilpiz D, Evans RM. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 1999; 98: 675-686.
Chan HM, La Thangue NB. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci 2001; 114: 2363-2373.
Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 1988; 240: 324-326.
Charlier TD, Lakaye B, Ball GF, Balthazart J. The steroid receptor coactivator SRC-1 exhibits a high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain. Neuroendocrinology 2002; 76: 297-315.
Charlier TD, Ball GF, Balthazart J. Inhibition of steroid receptor coactivator-1 blocks estrogen and androgen action on male sexual behavior and associated brain plasticity. J Neurosci 2005; 25: 906-913.
Charlier TD, Balthazart J, Ball GF. Sex difference in the distribution of the steroid receptor coactivator SRC-1 in the song control nuclei of male and female canaries. Brain Res 2003; 959: 263-274.
Chauchereau A, Amazit L, Quesne M, Guiochon-Mantel A, Milgrom E. Sumoylation of the progesterone receptor and of the coactivator SRC-1. J Biol Chem 2003; 278: 12335-12343.
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with p/CAF and CBP/p300. Cell 1997; 90: 569-580.
Chen SL, Dowhan DH, Hosking BM, Muscat GE. The steroid receptor coactivator, GRIP-1 is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Gen Dev 2000; 14: 1209-1228.
Chevillard-Briet M, Trouche D, Vandel L. Control of CBP co-activating activity by arginine methylation. EMBO J 2002; 21: 5457-5466.
Clark AS, Davis LA, Roy EJ. A possible physiological basis for the dud-stud phenomenon. Horm Behav 1985; 1: 227-230.
Conneely OM, Sullivan WP, Toft DO, Birnbaumer M, Cook RG, Maxwell BL, Zarucki-Schultz T, Greene GL, Schrader WT, O'Malley BW. Molecular cloning of the chicken progesterone receptor. Science 1986; 233: 767-770.
Cooke BM, Tabibnia G, Breedlove SM. A brain sexual dimorphism controlled by circulating androgens. Proc Natl Acad Sci USA 1999; 96: 7538-7540.
Coulthard VH, Matsuda S, Heery DM. An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220. J Biol Chem 2003; 278: 10942-10951.
Culig Z, Comuzzi B, Steiner H, Bartsch H, Hobisch A. Expression and function of androgen receptor co-activators in prostate cancer. J Steroid Biochem Mol Biol 2004; 92: 265-271.
Dellovade TL, Kia HK, Zhu Y-S, Pfaff DW. Thyroid hormone coadministration inhibits the estrogen-stimulated elevation of preproenkephalin mRNA in female rat hypothalamic neurons. Neuroendocrinology 1999; 70: 168-174.
Dellovade TL, Zhu Y-S, Kre L, Pfaff, DW. Thyroid hormone and estrogen interact to regulate behavior. Proc Natl Acad Sci USA 1996; 93: 12581-12586.
Dessi-Fulgheri F, Lucarini N, Lupo di Prisco C. Relationship between testosterone metabolism in the brain, other endocrine variables and internal aggression in mice. Aggress Behav 1976; 2: 223-231.
Ding X, Anderson C, Ma H, Hong H, Uht M, Kushner P, Stallcup M. Nuclear receptor-binding sites of co-activators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator-1 (SRC-1): multiple motifs with different binding specificities. Mol Endocrinol 1998; 12: 302-313.
Dowling ALS, Martz GU, Leonard JL, Zoeller RT. Acute changes in maternal thyroid hormone induce rapid and transient changes in specific gene expression in fetal rat brain. J Neurosci 2000; 20: 2255-2265.
Dowling ALS, Zoeller RT. Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain. Brain Res 2000; 82: 126-132.
Dussault I, Fawcett D, Matthyssen A, Bader JA, Giguere V. Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech Dev 1998; 70: 147-153.
Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-895.
Feder HH, Blaustein JD, Nock BL. Oestrogen-progestin regulation of female sexual behavior in guinea pig. J Steroid Biochem Mol Biol 1978; 11: 873-877.
Foidart A, Lakaye B, Grisar T, Ball GF, Balthazart J. Estrogen receptor-beta in quail: cloning, tissue expression and neuroanatomical distribution. J Neurobiol 1999; 40: 327-342.
Font de Mora J, Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 2000; 20: 5041-5047.
Gehin M, Mark M, Dennefeld C, Dierich A, Gronemeyer H, Chambon P. The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol 2002; 22: 5923-5937.
Gorski RA, Gordon JH, Shryne JE, Southam AM. Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 1978; 148: 333-346.
Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986; 320: 134-139.
Grunt JA, Young WC. Differential reactivity of individuals and the response of the male guinea pig to testosterone propionate. Endocrinology 1952; 51: 237-248.
Halachmi S, Marden E, Martin G, MacKay C, Abbondanz, C, Brown M. Estrogen receptor-associated proteins: possible mediator of hormone-induced transcription. Science 1994; 264: 1455-1458.
Heery D, Kalkhoven E, Hoare S, Parker M. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997; 387: 733-736.
Hong H, Kohli K, Garabedian MJ, Stallcup MR. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoids and vitamin D receptors. Mol Cell Biol 1997; 17: 2735-2744.
Howard SB, Etgen AM, Barfield RJ. Antagonism of central estrogen action by intracerebral implants of tamoxifen. Horm Behav 1984; 16: 256-266.
Iannacone E, Yan A, Gauger K, Dowling A, Zoeller R. Thyroid hormone exerts site-specific effects on SRC-1 and NCoR expression selectively in the neonatal rat brain. Mol Cell Endocrinol 2002; 186: 49-59.
Jensen EV, Suzuki T, Kawashima T, Stumpf WE, Jungblut PW, DeSombre ER. A two-step mechanism for the interaction of estradiol with rat uterus. Proc Natl Acad Sci USA 1968; 59: 632-638.
Jezierski MK, Sohrabij F. Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation. Neurobiol Aging 2001; 22: 311-321.
Kalkhoven E, Valentine J, Heery D, Parker M. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J 1998; 17: 232-243.
Kamei Y, Xu L, Heinzel, T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman R, Rose D, Glass C, Rosenfeld M. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 1996; 85: 403-414.
Kim H-J, Kim JH, Lee JW. Steroid receptor coactivator1 interacts with serum response factor and co-activates serum response element-mediated transactivation. J Biol Chem 2000; 44: 28564-28567.
Klinge CM, Jernigan SC, Mattingly KA, Risinger KE, Zhang J. Estrogen response element-dependent regulation of transcriptional activation of estrogen receptor α and β by coactivators and corepressors. J Mol Endocrinol 2004; 33: 387-410.
Koh S, Chen D, Lee Y-H, Stallcup MR. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyl transferase activities. J Biol Chem 2002; 277: 26031-26035.
Koibuchi N, Chin WW. ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation. Endocrinology 1998; 139: 2335-2341.
Koibuchi N, Chin WW. Thyroid hormone action and brain development. Trends Endocrinol Metab 2000; 11: 123-128.
Kotaja N, Karvonen U, Janne OA, O'Malley BW. The nuclear receptor interacting domain of GRIP1 is modulated by covalent attachment of SUMO-1. J Biol Chem 2002; 277: 30283-30288.
Kurihara I, Shibata H, Suzuki T, Ando T, Kobayashi S, Hayashi M, Saito I, Saruta T. Expression and regulation of nuclear receptor coactivators in glucocorticoid action. Mol Cell Endocrinol 2002; 189: 181-189.
Lauber AH, Romano GJ, Mobbs CV, Howells RD, Pfaff DW. Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat. Mol Brain Res 1990; 8: 47-54.
Lauber AH, Romano GJ, Pfaff DW. Sex difference in estradiol regulation of progestin receptor messenger RNA in rat mediobasal hypothalamus as demonstrated by in situ hybridization. Neuroendocrinology 1991; 53: 608-613.
Lee SK, Kim H-J, Na, SY, Kim TS, Choi HS, Im SY, Lee JW. Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with c-Jun and c-Fos subunits. J Biol Chem 1998; 273: 16651-16654.
Leo C, Don Chen J. The SRC family of nuclear receptors coactivators. Gene 2000; 245: 1-11.
Li H, Don Chen, J. The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation. J Biol Chem 1998; 273: 5948-5954.
Li, H Gomes PJ, Don Chen J. RAC3, a steroid/nuclear receptor receptor-associated coactivator that is related to SRC-1 and TIF-2. Proc Natl Acad Sci USA 1997; 94: 8479-8484.
Li J, O'Malley BW, Wong J. p300 requires its histone acetyl transferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin. Mol Cell Biol 2000; 20: 2031-2042.
Li X, Wong J, Tsai SY, Tsai M-J, O'Malley BW. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol 2003; 23: 3763-3773.
Lubahn DB, Joseph DT, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 1988; 240: 327-330.
Ma H, Baumann CT, Li H, Strahl BD, Rice R, Jelinek MA, Aswad DW, Allis CD, Hager GL, Stallcup MR. Hormone-dependant, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Curr Biol 2001; 11: 1981-1985.
MacLusky NJ, McEwen BS. Oestrogen modulates progestin receptor concentration in some brain regions but not in others. Nature 1978; 274: 276-278.
Maden M, Holder N. Retinoic acid and development of the central nervous system. Bioessays 1992; 14: 431-438.
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835-839.
Martinez de Arrieta C, Koibuchi N, Chin WW. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effects of thyroid status. Endocrinology 2000; 141: 1693-1698.
Matsumoto AM. Age-related change in nuclear receptor coactivator immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus. Brain Res 2002; 943: 202-205.
Matthews SG. Dynamic change in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain. Dev Brain Res 1998; 107: 123-132.
McCarthy MM, Schlenker EH, Pfaff DW. Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain. Endocrinology 1993; 133: 433-439.
McDonnel DP, Mangelsdorf DJ, Pike JW, Haussler MR, O'Malley BW. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 1987; 235: 1214-1217.
McEwen, BS. Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol 2001; 91: 2785-2801.
McKenna N, Nawaz Z, Tsai SY, Tsai M-J, O'Malley BW. Distinct steady-state nuclear receptor coregulator complexes exist in vivo. Proc Natl Acad Sci USA 1998; 95: 11697-11702.
McKenna NJ, Lanz B, O'Malley BW. Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 1999; 20: 321-344.
McKenna NJ, O'Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 2002; 108: 465-474.
Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, De Kloet ER. Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling. Endocrinology 2005; 146: 1438-1448.
Meijer OC, Steenbergen PJ, De Kloet ER. Differential expression and regional distribution of steroid receptor coactivor SRC-1 and SRC-2 in the brain and pituitary. Endocrinology 2000; 141: 2192-2199.
Meyer ME, Gronemeyer H, Turcotte B, Bocquel M-T, Tasset D, Chambon P. Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 1989; 57: 433-442.
Misiti, S, Koibuchi N, Bei M, Farsetti A, Chin WW. Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development. Endocrinology 1999; 140: 1957-1960.
Misiti S, Shomburg L, Yen PM, Chin WW. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology 1998; 139: 2493-2500.
Mitev YA, Wolf SS, Almeida OFX, Patchev VK. Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the rat brain. FASEB J 2003; 17: 518-519.
Molenda HA, Griffin AL, Auger AP, McCarthy MM, Tetel MJ. Nuclear receptor coactivators modulate hormone-dependent gene expression in brain and female reproductive behavior in rats. Endocrinology 2002; 143: 436-444.
Molenda HA, Williams CA, Rebidue R, Blaustein JD, Tetel MJ. Nuclear receptor coactivators function in estrogen and progestin receptor-dependent sexual behaviors in female rats. Society for Neuroscience, New Orleans, 2003, Abstract no. 726.9.
Monks DA, Xu J, O'Malley BW, Jordan CL. Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons. Neuroendocrinology 2003; 78: 45-51.
Murphy SD, Kilts CP, Molenda HA, Tetel MJ. Confocal analysis of neuronal expression of nuclear receptor coactivators and steroid receptors in rat hypothalamus. Society for Neuroscience, New Orleans, 2003, Abstract no. 726.8.
Na S-Y, Lee SK, Han SJ, Choi HS, Im SY, Lee JW. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivation. J Biol Chem 1998; 273: 10831-10834.
Needha M, Raines S, McPheat J, Stacey C, Ellston J, Hoare S, Parker M. Differential interaction of steroid hormone receptors with LXXLL motifs in SRC-1a depends on residues flanking the motif. J Steroid Bioch Mol Biol 2000; 72: 35-46.
Nicot A, Ogawa SYB, Carr K, Pfaff DW. Effects of an intrahypothalamic injection of antisense oligonucleotides for preproenkephalin mRNA in female rats: evidence for opioid involvement in lordosis reflex. Brain Res 1997; 777: 60-68.
Nishihara E, Yoshida-Komiya H, Chang C-SC, Liao L, Davis RL, O'Malley BW, Xu J. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci 2003; 23: 213-222.
Nottebohm F. Testosterone triggers growth of brain vocal control nuclei in adult female canaries. Brain Res 1980; 189: 429-436.
Nottebohm F. A brain for all seasons: cyclical anatomical changes in song control nuclei of the canary brain. Science 1981; 214: 1368-1370.
O'Bryant EL, Jordan CL. Expression of nuclear receptor coactivators in androgen-responsive and -unresponsive motoneurons. Horm Behav 2005; 47: 59-72.
Ogawa H, Nishi M, Kawata M. Localization of nuclear coactivator p300 and steroid receptor coactivator 1 in the rat hippocampus. Brain Res 2001; 890: 197-202.
Ogawa S, Olazabal UE, Parhar IS, Pfaff DW. Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone immunoreactivity in female rat. J Neurosci 1994; 14: 1766-1774.
Oñate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW. The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. J Biol Chem 1998; 273: 12101-12108.
Oñate SA, Tsai SY, Tsai M-J, O'Malley BW. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 1995; 270: 1354-1357.
Oppenheimer JH, Schwartz HL. Molecular basis of thyroid hormone-dependent brain development. Endocr Rev 1997; 18: 462-475.
Panzica GC, Castagna C, Aste N, Viglietti-Panzica C, Balthazart J. Testosterone effects on the neuronal ultrastructure in the medial preoptic nucleus of the male Japanese quail. Brain Res Bull 1996; 39: 281-292.
Panzica GC, Viglietti-Panzica C, Balthazart J. The sexually dimorphic medial preoptic nucleus of quail: a key brain area mediating steroid action on male sexual behavior. Front Neuroendocrinol 1996; 17: 51-125.
Panzica GC, Viglietti-Panzica C, Sanchez F, Sante P, Balthazart J. Effects of testosterone on a selected neuronal population within the preoptic sexually dimorphic nucleus of the Japanese quail. J Comp Neurol 1991; 303: 443-456.
Parsons B, MacLusky NJ, Krey L, Pfaff DW, McEwen BS. The temporal relationship between estrogen-inducible progestin receptors in the female rat brain and the time course of estrogen activation of mating behavior. Endocrinology 1980; 107: 774-779.
Petkovich M, Brand NJ, Krust A, Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987; 330: 444-450.
Pfaff DW, Keiner M. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J Comp Neurol 1973; 151: 121-158.
Pfaff DW, Sakuna Y. Deficit in the lordosis reflex of female rats caused by lesion in the ventromedial nucleus of the hypothalamus. J Physiol 1979; 288: 203-210.
Pleim ET, Brown TJ, MacLusky NJ, Etgen AM, Barfield RJ. Dilute estradiol implants and progestin receptor induction in the ventromedial nucleus of the hypothalamus: correlation with receptive behavior in female rats. Endocrinology 1989; 124: 1807-1812.
Pollio G, Xue P, Zanisi M, Nicolin A, Maggi A. Antisense oligonucleotide blocks progesterone-induced lordosis behavior in ovariectomized rats. Brain Res Mol Brain Res 1993; 19: 135-139.
Ranson RN, Santer RM, Watson HD. SRC-1 localisation in lumbosacral spinal cord of male and female Wistar rats. NeuroReport 2003; 14: 1821-1824.
Romano GJ, Mobbs CV, Howells RD, Pfaff DW. Estrogen regulation of proenkephalin gene expression in the ventromedial hypothalamus of the rat: temporal qualities and synergism with progesterone. Mol Brain Res 1989; 5: 51-58.
Rowan BG, Garrison N, Weigel NL, O'Malley BW. 8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Mol Cell Biol 2000; 20: 8720-8730.
Sachs BD, Pollak EK, Krieger MS, Barfield RJ. Sexual behavior: normal male patterning in androgenized female rats. Science 1973; 181: 770-772.
Sachs BD, Thomas DA. Differential effects of perinatal androgen treatment on sexually dimorphic characteristics in rats. Physiol Behav 1985; 34: 735-742.
Schumacher M, Balthazart J. The effects of testosterone and its metabolites on sexual behavior and morphology in male and female Japanese quail. Physiol Behav 1983; 30: 335-339.
Setiawan E, Owen D, McCabe L, Kostaki A, Andrews MH, Matthews SG. Glucocorticoids do not alter developmental expression of hippocampal or pituitary steroid receptor coactivator-1 and -2 in the late gestation fetal guinea pig. Endocrinology 2004; 145: 3796-3803.
Shearman LP, Zylka MJ, Reppert SM, Weaver DR. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus. Neuroscience 1999; 89: 387-397.
Simerly RB. Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci 2002; 25: 507-536.
Sodersten P. Effects of anti-oestrogen treatment of neonatal male rats on lordosis behaviour and mounting behaviour in the adult. J Endocrinol 1978; 76: 241-249.
Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou JX, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai M-J, O'Malley BW. Steroid receptor coactivator 1 is a histone acetyltransferase. Nature 1997; 389: 194-198.
Suen C-S, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle R, Frail DE. A transcription coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem 1998; 273: 27645-67653.
Takeshita A, Cardonna GR, Koibuchi N, Suen C-S, Chin WW. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem 1997; 272: 27629-27634.
Tanenbaum DM, Wang Y, Williams SP, Sigler PB. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domain. Proc Natl Acad Sci USA 1998; 95: 5998-6003.
Tetel MJ, Ungar TC, Hassan B, Bittman EL. Photoperiodic regulation of androgen receptor and steroid receptor coactivator-1 in Siberian hamster brain. Mol Brain Res 2004; 131: 79-87.
Torchia J, Rose DW, Inostrazo J, Kamei Y, Westin S, Glass CK, Rosenfeld, MG. The transcriptional coactivator p/CIP binds CBP and mediates nuclear-receptor function. Nature 1997; 387: 677-684.
Tramontin AD, Hartman VN, Brenowitz EA. Breeding conditions induce rapid and sequential growth in adult song control circuits: a model of seasonal plasticity in the brain. J Neurosci 2000; 20: 854-861.
Tsai M-J, O'Malley BW. Molecular mechanism of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994; 63: 451-486.
van der Schoot P. Effects of dihydrotestosterone and oestradiol on sexual differentiation in male rats. J Endocrinol 1980; 84: 397-407.
Vasudevan N, Zhu Y-S, Daniel S, Koibuchi N, Chin WW, Pfaff D. Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of preproenkephalin gene. J Neuroendocrinol 2001; 13: 779-790.
Viglietti-Panzica C, Aste N, Balthazart J, Panzica GC. Vasotocinergic innervation of sexually dimorphic medial preoptic nucleus of the male Japanese quail: influence of testosterone. Brain Res 1994; 657: 171-184.
Viglietti-Panzica C, Balthazart J, Plumari L, Fratesi S, Absil P, Panzica GC. Estradiol mediates effects of testosterone on vasotocin immunoreactivity in the adult quail brain. Horm Behav 2001; 40: 445-461.
Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J 1998; 17: 507-519.
Walker C-D, Welberg LAM, Plotsky PM. Glucocorticoid, stress and development. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, Brain and Behavior. San Diego, CA: Academic Press, 2002; 4: 487-534.
Ward IL, Renz FJ. Consequences of perinatal hormone manipulation on the adult sexual behavior of female rats. J Comp Physiol Psychol 1972; 78: 349-355.
Weigel NL. Steroid hormone receptors and their regulation by phosphorylation. Biochem J 1996; 319: 657-667.
Weinberger C, Hollenberg SM, Rosenfeld MG, Evans RM. Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. Nature 1985; 318: 670-672.
Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ, Evans RM. The c-erb-A encodes a thyroid hormone receptor. Nature 1986; 324: 641-646.
Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S. Mice deficient in the steroid receptor coactivator 1 (SRC-1) are resistant to thyroid hormone. EMBO J 1999; 18: 1900-1904.
Westin S, Rosenfeld MG, Glass CK. Nuclear receptor coactivators. Adv Pharmacol 2000; 47: 89-112.
Whalen RE, Edwards DA. Hormonal determinant of the development of masculine and feminine behavior in male and female rats. Anat Rec 1967; 157: 173-180.
Wu RC, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai M-J, O'Malley BW. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by IκB kinase. Mol Cell Biol 2002; 22: 3549-3561.
Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai M-J, O'Malley BW. Selective phosphorylation of the SRC-3/AIB1 coactivator integrated genomic responses to multiple cellular signaling pathways. Mol Cell 2004; 15: 937-949.
Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci USA 2000; 97: 6379-6384.
Xu J, O'Malley BW. Molecular mechanisms and cellular biology of the steroid receptor co-activator (SRC) family in steroid receptor function. Rev Endocrinol Metab Dis 2002; 3: 185-192.
Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai M-J, O'Malley BW. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 1998; 279: 1922-1925.
Yanase M, Gorski RA. Sites of estrogen and progesterone facilitation of lordosis behavior in the spayed rat. Biol Reprod 1976; 15: 536-543.
Yousefi B, Jingu H, Ohta M, Umezu M, Koibuchi N. Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex. Thyroid 2005; 15: 314-319.
Zambrano IA, Rutledge EM, Zehr JL, Tetel MJ, Sisk CL. Age and hormones interact to regulate steroid receptor coactivator-1 (SRC-1) expression in the amygdala and hypothalamus. Society for Neurosciences, San Diego, 2004, Abstract no. 758.8.
Zelterstrom RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlman T. Dopamine neuron agenesis in Nurr1-deficient mice. Science 1997; 276: 248-250.
Zhang H, Yi X, Sun X, Yin N, Shi B, Wu H, Wang D, Wu G, Shang Y. Differential gene regulation by the SRC family of coactivators. Genes Dev 2004; 18: 1753-1765.
Zhou C, Qiu Y, Pereira FA, Crair MC, Tsai SY, Tsai M-J. The nuclear orphan receptor COUP-TF1 is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron 1999; 24: 847-859.