Modulation of hormonal signaling in the brain by steroid receptor coactivators.

Animals; Gene Expression Regulation; Histone Acetyltransferases; Nuclear Receptor Coactivator 2/genetics/metabolism; Preoptic Area/cytology/metabolism; Receptors, Steroid/genetics/metabolism; Sexual Behavior, Animal/physiology; Signal Transduction/physiology; Steroids/metabolism; Trans-Activators/genetics/metabolism; Transcription Factors/genetics/metabolism

Abstract :

[en] Nuclear receptors, such as estrogen, glucocorticoid or thyroid hormone receptors, have been shown to play a critical role in brain development and physiology. The activity of these receptors is modulated by the interaction with several proteins and, in particular, coactivators are required to enhance their transcriptional activity. The steroid receptor coactivators (SRC-1, -2 and -3) are currently the best characterized coactivators and we review here the current knowledge on the distribution and function of these proteins in the brain. Knock-out models and antisense techniques have demonstrated the requirement for SRC-1 and -2 in the brain, focusing mainly on steroid and thyroid hormone-dependent development and behavior. The precise function of SRC-3 in the brain is currently unknown but its presence throughout the brain suggests an important function. Although the molecular biology of SRCs is relatively well known, the in vivo control of their expression, post-translational modifications and time- and cell-specific interactions with the different nuclear receptors remain elusive. A complete understanding of hormone action on brain and behavior will not be attained until a better knowledge of coactivator physiology is achieved.

Disciplines :

Neurosciences & behavior

Author, co-author :

Charlier, Thierry ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau

Language :

English

Title :

Modulation of hormonal signaling in the brain by steroid receptor coactivators.

Publication date :

2005

Journal title :

Reviews in the Neurosciences

ISSN :

0334-1763

eISSN :

2191-0200

Publisher :

Freund Publishing House Ltd, London, United Kingdom

Volume :

Issue :

Pages :

339-57

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 June 2009

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