Reference : Le role de la genetique et de l'environnement dans le developpement de l'endometriose.
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Le role de la genetique et de l'environnement dans le developpement de l'endometriose.
[en] Role of genetic and environmental factors in the development of endometriosis
Ballester, M. [> >]
Dehan, Pierre mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
BELIARD, Aude mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Brichant, Géraldine [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Nisolle, Michelle mailto [Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique >]
Revue Médicale de Liège
Université de Liège. Revue Médicale de Liège
Yes (verified by ORBi)
[en] Animals ; Endometriosis/epidemiology/etiology/genetics ; Environment ; Epigenesis, Genetic/physiology ; Female ; Gene-Environment Interaction ; Humans ; Risk Factors ; Uterine Diseases/epidemiology/etiology/genetics
[en] Endometriosis is usually described as a complex multifactorial disease involving dysregulation of estrogen metabolism, inflammatory and immunological mechanisms. Recently, many authors have questioned the environmental pollution and toxins in the formation and development of endometriotic lesions. Therefore, while dioxins and PCBs have been implicated, insufficient data are available until now to confirm this theory. Endometriosis has also been considered as a genetic disease. Indeed, early familial aggregation and twin studies noted a higher risk of endometriosis among relatives. However, demonstration of a genetic component in the pathogenesis of such a multifactorial disease is quite difficult due to many limitations such as ethnic differences, involvement of environmental factors and size of needed patients cohorts. Over the last decade, the epigenetic approach (DNA methylation, histones modifications and microRNA) has allowed to consider many new perspectives. Indeed, dysregulation (hyper- or hypomethylation) of many genes has already been highlighted. This method of analysis is the subject of numerous studies in order to develop diagnostic, prognostic and therapeutic tools for this disease which is becoming a real public health problem.

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