Reference : HOX Gene Aberrant Expression in Skin Melanoma: A Review.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/137972
HOX Gene Aberrant Expression in Skin Melanoma: A Review.
English
PIERARD, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Franchimont, Claudine mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
2012
Journal of skin cancer
2012
707260
Yes
International
2090-2913
2090-2913
United States
[en] The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis. A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). They are involved in cell proliferation and progression in the CMM metastatic path. We present relevant peer-reviewed literature findings about the aberrant expression of HOX genes in CMM. The number of CMM cell nuclei exhibiting aberrant HOX protein expression appears correlated with tumour progression.
http://hdl.handle.net/2268/137972
10.1155/2012/707260

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