Partitioning of pulmonary resistance in Friesian calves

Eight right cranial lobes of healthy Friesian calves were suspended in an airtight box. They were inflated at a constant transpulmonary pressure (Ptp) and ventilated from the outside by modifying pressures in the box with a quasi-sinusoidal pump at a frequency of 30 counts per minute. Peak-to-peak changes were 0.5 kPa. Lobar resistance (Rl) was partitioned into three components: central airway resistance (Rc), small airway resistance (Rp) and tissue resistance (Rt). Partitioning of R1 was realised at six different lung volumes. Minimal R1 was observed for a value of Ptp between 0.5 and 0.7 kPa. At a Ptp of 0.5 kPa, Rc, Rp, Rt represent 30, 15 and 55 per cent of R1, respectively. Lobar resistance increases at high and low lung volumes. Small airway resistance is small and independent of the level of lung inflation, except at low lung volumes where a marked increase is observed. Tissue resistance is relatively high and responsible for the increase of R1 at high lung volumes. Central airway resistance does not change significantly with lung volumes