Reference : Investigation of the effects of histamine inhalation on the tracheobronchial tree of ...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Investigation of the effects of histamine inhalation on the tracheobronchial tree of calves by the forced oscillation technique.
Gustin, Pascal mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
Dhem, A.R. [> > > >]
Lekeux, Pierre mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
Lomba, F. [> > > >]
Landser, F.J. [> > > >]
Van de Woestijne, K. P. [> > > >]
Journal of Veterinary Pharmacology and Therapeutics
Blackwell Publishing
Yes (verified by ORBi)
[en] Administration, Inhalation ; Airway Resistance/drug effects ; Animals ; Bronchi/drug effects ; Cattle/physiology ; Histamine/administration & dosage/pharmacology ; Lung Compliance/drug effects ; Respiratory Function Tests/methods/veterinary ; Trachea/drug effects
[en] Effects of histamine inhalation were investigated with two different techniques in nine conscious, healthy calves. The oesophageal balloon technique was used to measure the dynamic respiratory compliance (Cdyn) and the pulmonary resistance (RL). The reactance (Xrs) and the resistance (Rrs) of the respiratory system were measured at high frequencies by the forced oscillation technique. These parameters were recorded before and after histamine inhalation. Three histamine dihydrochloride solution concentrations were used (16 mg/ml; 32 mg/ml; 64 mg/ml). Histamine inhalation induced a decrease in Cdyn and Xrs an increase in Rrs, RL and of the resonant frequency and a negative frequency dependence of Rrs. Some of these changes were satisfactorily correlated with the histamine solution concentrations. The resonant frequency was well correlated with Cdyn. It was concluded that histamine inhalation induces a decrease of the calibre of small and large airways and a non-homogeneous behaviour of the pulmonary ventilation in awake calves. The forced oscillation technique can be used to perform an inhalation provocation test in unsedated animals.
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