Acute effects of Parlodel-LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma.
Abs, R.; Parizel, P. M.; Beckers, Albert
1991 • In Journal of Endocrinological Investigation, 14 (2), p. 135-8
[en] A 68-year-old male patient presented with visual impairment due to a large pituitary tumor. After transsphenoidal adenomectomy the elevated serum FSH levels were lowered but not normalized. Deterioration of the vision was detected five years later and tumor regrowth was evidenced. The patient was treated with the long-acting and repeatable form of bromocriptine (Parlodel-LAR). Three days after the first intramuscular injection it already resulted in an important improvement of the visual field defects. Serum FSH concentration was suppressed during a prolonged period, but no change in the size of the pituitary adenoma was recorded on CT scan. Long-term oral treatment with bromocriptine resulted in a sustained suppression of the serum FSH levels, without further visual improvement, but with a significant reduction of the volume of the adenoma. The rapid and prolonged effect of Parlodel-LAR upon the FSH secretion, with a possible correction of the visual field defects and a reduction of the tumor mass, could make this medication appropriate as adjunctive treatment in some gonadotroph cell adenomas.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Abs, R.
Parizel, P. M.
Beckers, Albert ; Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Language :
English
Title :
Acute effects of Parlodel-LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma.
Beckers A., Stevenaert A., Mashiter K., Hennen G. (1985) Follicle-stimulating hormone-secreting pituitary adenomas. J. Clin. Endocrinol. Metab. 61:525.
Snyder P.J. (1985) Gonadotroph cell adenomas of the pituitary. Endocr. Rev. 6:552.
Harris R.I., Schatz N.J., Gennarelli T., Savino P.J., Cobbs W.H., Snyder P.J. (1983) FSH-secreting pituitary adenomas: correlation of reduction of adenoma size with reduction of hormonal hypersecretion after transsphenoidal surgery. J. Clin. Endocrinol. Metab. 56:1288.
Vos P., Croughs R.J.M., Thijssen J.H.H., van’t Verlaat J.W., van Ginkel L.A. (1988) Response of luteinizing hormone secreting pituitary adenoma to a long-acting somatostatin analogue. Acta Endocrinol. (Copenh.) 118:587.
Sassolas G., Serusclat P., Claustrat B., Trouillas J., Merabet S., Cohen R., Souquet J.C. (1988) Plasma alpha-subunit levels during the treatment of pituitary adenomas with the somatostatin analogue SMS 201–995. Horm. Res. 29:124.
Berezin M., Olchovsky D., Pines A., Tadmor R., Lunenfeld B. (1984) Reduction of follicle-stimulating hormone secretion in FSH-producing pituitary adenoma by bromocriptine. J. Clin. Endocrinol. Metab. 59:1220.
Chapman A.J., MacFarlane I.A., Shalet S.M., Beardwell C.G., Dutton J. (1984) Sutton M.L. Discordant serum alpha-subunit and FSH concentrations in a woman with a pituitary tumour. Clin. Endocrinol. (Oxf.) 21:123.
Vance M.L., Ridgway E.C., Thorner M.O. (1985) Follicle-stimulating hormone- and alpha-subunit-secreting pituitary tumor treated with bromocriptine. J. Clin. Endocrinol. Metab. 61:580.
Oppenheim D.S., Klibanski A. (1989) Medical therapy of glycoprotein hormone-secreting pituitary tumors. Endocrinol. Metab. Clin. North. Am. 18:339.
Del Pozo E., Schluter K., Nuesch E., Rosenthaler J., Kerp L. (1986) Pharmacokinetics of a long-acting bromocriptine preparation (Parlodel LA) and its effect on release of prolactin and growth hormone. Eur. J. Clin. Pharmacol. 29:615.