[en] The aim of this study is the development of a high-density bolus to be given to lambs in order to release sulfamethazine during 4 days after a single oral administration. The suitability of 12 lipid matrix formulations was assessed in order to maintain the integrity of the tablet even after complete dissolution of the active substance. The influence of both nature and concentration of the lipid excipient on the in vitro release of sulfamethazine was investigated. The influences of the granulation method and of the compression force were assessed on a formulation containing Cutina® HR as a binding and sustained-release agent. Finally, stability tests showed that the in vitro release characteristics remain unchanged during storage.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
In vitro evaluation of lipid matrices for the development of a sustained-release sulfamethazine bolus for lambs
Publication date :
1996
Journal title :
Drug Development and Industrial Pharmacy
ISSN :
0363-9045
eISSN :
1520-5762
Publisher :
Taylor & Francis, Philadelphia, United States - Pennsylvania
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
M. W. Gregory, L. P. Joyner, and J. Catchpole, Vet. Res. Commun., 5, 307 (1982).
S. C. Misra and O. P. Gautam, Ind. J. Microbiol, 10, 101 (1970).
R. J. Gyurick, Rumen Retention Devices: Fundamentals and Applications, Dekker, New York, 1988.
M. S. Bulgin V. M. Lane, T. F. Archer, J. D. Baggot, and A. L. Craigmill, J. Vet. Pharmacol. Ther., 14, 36 (1991).
J. R. Cardinal, J. Controlled Release 2, 393 (1985).
J. L. Rinner, R. L. Byfort, L. G. Stratton, and J. A. Hair, Am. J. Vet. Res., 43, 2028 (1982).
E. Doelker and P. Buri, Pharm. Acta Helv., 56, 111 (1981).
A. Pommier, C. Brossard, J. Ser, and D. Duchene, STP Pharma, 5, 384 (1988).
F. Goodhart, R. McCoy, and F. Ninger, J. Pharm. Sci., 63(11), 1748(1974).
K. Javaid, J. Fincher, and C. Hartman, J. Pharm. Sci., 60(11), 1709(1971).
B. Evrard and L. Delattre, in 6th International Conference on Pharmaceutical Technology, vol. 3, Paris, 1992, p. 187.
P. Holm, Drug Devel. Ind. Pharm., 13(9-11), 1675 (1987).
B. Evrard, J. P. Dechesne, X. Fargetton, N. Zygraich, and L. Delattre, in 5th International Conference on Pharmaceutical Technology, Paris, 1989, p. 294.
T. Higuchi, J. Pharm. Sci., 52, 1145 (1963).
J. L. Terrier, P. Toure, J. Meimoun, D. Duchene, and F. Puisieux, Pharm. Acta Helv., 50(7-8), 219 (1975).
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
