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Autonomous electrical activity induced by cardiac tissue deformation in a thermo-electro-mechanical background
Collet, Arnaud; Desaive, Thomas; Dauby, Pierre
2012In 8th IFAC Symposium on Biological and Medical Systems
Peer reviewed
 

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Keywords :
Biomedical systems; Electrical activity; Finite element analysis; Mechanical properties; Nonlinear models; Numerical simulation; Partial differential equations; Physiological models
Abstract :
[en] In a healthy heart, the mechano-electric feedback (MEF) process acts as an intrinsic regulatory mechanism of the myocardium which allows the normal cardiac contraction by damping mechanical perturbations in order to generate a new healthy electromechanical situation. However, under certain conditions, the MEF can be a generator of dramatic arrhythmias by inducing local electrical depolarizations as a result of abnormal cardiac tissue deformations, via stretch-activated channels (SACs). Then, these perturbations can propagate in the whole heart and lead to global cardiac dysfunctions. In the present study, we examine the spatio-temporal behavior of the autonomous electrical activity induced by the MEF when the heart is subject to temperature variations. For instance, such a situation can occur during a therapeutic hypothermia. This technique is usually used to prevent neuronal injuries after a cardiac resuscitation. From this perspective, we introduce a one-dimensional time-dependent model containing all the key ingredients that allow accounting for excitation-contraction coupling, MEF and thermoelectric coupling. Our simulations show that an autonomous electrical activity can be induced by cardiac deformations, but only inside a certain temperature interval. In addition, in some cases, the autonomous electrical activity takes place in a periodic way like a pacemaker. We also highlight that some properties of the action potentials that are generated by the MEF, are significantly influenced by temperature. Moreover, in the situation where a pacemaker activity occurs, we also show that the period is heavily temperature-dependent.
Research center :
GIGA-Cardiovascular Sciences
Thermodynamics of Irreversible Processes
Disciplines :
Cardiovascular & respiratory systems
Mechanical engineering
Author, co-author :
Collet, Arnaud ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Dauby, Pierre  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Autonomous electrical activity induced by cardiac tissue deformation in a thermo-electro-mechanical background
Alternative titles :
[fr] Activité électrique autonome induite par les déformations du tissu cardiaque dans un environnement thermo-électro-mécanique
Publication date :
August 2012
Event name :
BMS 2012: 8th IFAC Symposium on Biological and Medical Systems
Event place :
Budapest, Hungary
Event date :
29-31 August
By request :
Yes
Audience :
International
Main work title :
8th IFAC Symposium on Biological and Medical Systems
Peer reviewed :
Peer reviewed
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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since 08 December 2012

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