Article (Scientific journals)
Placental growth factor: a tissue modelling factor with therapeutic potentials in neurology?
Chaballe, Linda; Schoenen, Jean; Franzen, Rachelle
2011In Acta Neurologica Belgica, 111 (1), p. 10-7
Peer Reviewed verified by ORBi
 

Files


Full Text
Proof1.pdf
Publisher postprint (364.16 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Disease Models, Animal; Humans; Mice; Models, Biological; Nervous System Diseases/drug therapy/metabolism; Neuroglia/drug effects/physiology; Neurology; Neuroprostanes/metabolism/therapeutic use; Pregnancy Proteins/chemistry/metabolism/therapeutic use; Receptors, Vascular Endothelial Growth Factor/metabolism/therapeutic use
Abstract :
[en] Placental growth factor (PlGF) is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides its well known capacity to potentiate the angiogenic action of VEGF, PlGF also participates in inflammatory processes by attracting and activating monocytes; it plays therefore more specifically a role in pathological conditions. PIGF and its two receptors, VEGFR-1 and neuropilins (NRPs), are expressed in the brain and increase after experimental stroke, but their precise functions in the nervous system remain underexplored. In this review article, we summarize present knowledge on the role of PlGF in various nervous system disease processes. Given the available data, P1GF has neuroprotective and neurotrophic properties that make it an actor of considerable interest in the pathophysiology and potentially in the therapy of degenerative and traumatic brain or spinal cord diseases.
Disciplines :
Neurosciences & behavior
Author, co-author :
Chaballe, Linda ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Franzen, Rachelle  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Placental growth factor: a tissue modelling factor with therapeutic potentials in neurology?
Publication date :
2011
Journal title :
Acta Neurologica Belgica
ISSN :
0300-9009
eISSN :
2240-2993
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
111
Issue :
1
Pages :
10-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2012

Statistics


Number of views
80 (2 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
13
Scopus citations®
without self-citations
13

Bibliography


Similar publications



Contact ORBi