[en] Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1M KCl over the occipital cortex and the number of CSDs occurring over a 2h period was compared to the previously assessed open field behavior. Higher anxiety-like behavior was significantly correlated with a higher frequency of KCl-induced CSDs. In saline-treated animals, fewer rearings were found in animals with more frequent CSDs (R=-1.00). The duration of ambulatory episodes in the open field center correlated negatively with number of CSDs in the valproate group (R=-0.83; p<0.005) and in riboflavin treated group (R=-0.69; p<0.05) as well as total time spent in the open field center in both groups (R=-0.75; p<0.05 and R=-0.58; p<0.1 respectively). These results suggest that anxiety symptoms are associated with susceptibility to CSD and might explain why it can be an aggravating factor in migraine with aura.
Disciplines :
Neurosciences & behavior
Author, co-author :
Bogdanov, Volodymyr Borysovych
Bogdanova, Olena Viktorivna
Koulchitsky, Stanislav ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Chauvel, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Multon, Sylvie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie
Makarchuk, Mykola Yukhymovych
Brennan, Kevin Christopher
Renshaw, Perry Franklin
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.
Publication date :
2013
Journal title :
Behavioural Brain Research
ISSN :
0166-4328
eISSN :
1872-7549
Publisher :
Elsevier, Netherlands
Volume :
236
Issue :
1
Pages :
90-3
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2012 Elsevier B.V. All rights reserved.
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Bibliography
Baskin S.M., Smitherman T.A. Migraine and psychiatric disorders: comorbidities, mechanisms, and clinical applications. Neurological Sciences 2009, 30(Suppl. 1):S61-S65.
Casucci G., Villani V., Finocchi C. Therapeutic strategies in migraine patients with mood and anxiety disorders: physiopathological basis. Neurological Sciences 2010, 31:S99-S101.
Merikangas K.R., Angst J., Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Archives of General Psychiatry 1990, 47:849-853.
Wassermann E.M., Greenberg B.D., Nguyen M.B., Murphy D.L. Motor cortex excitability correlates with an anxiety-related personality trait. Biological Psychiatry 2001, 50:377-382.
Bogdanov V.B., Multon S., Chauvel V., Bogdanova O.V., Prodanov D., Makarchuk M.Y., et al. Migraine preventive drugs differentially affect cortical spreading depression in rat. Neurobiology of Disease 2010, 41:430-435.
Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal of Pharmacology 2003, 463:3-33.
Bouwknecht J.A., Spiga F., Staub D.R., Hale M.W., Shekhar A., Lowry C.A. Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus. Brain Research Bulletin 2007, 72:32-43. [Epub 2007 Jan 16].
Thiel C.M., Muller C.P., Huston J.P., Schwarting R.K. High versus low reactivity to a novel environment: behavioural, pharmacological and neurochemical assessments. Neuroscience 1999, 93:243-251.
Kalueff A.V., Fox M.A., Gallagher P.S., Murphy D.L. Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes, Brain and Behavior 2007, 6:389-400. [Epub 2006 Aug 29].
Barros H.M., Tannhauser S.L., Tannhauser M.A., Tannhauser M. Effect of sodium valproate on the open-field behavior of rats. Brazilian Journal of Medical and Biological Research 1992, 25:281-287.
Vinogradova L.V., Kuznetsova G.D., Coenen A.M. Unilateral cortical spreading depression induced by sound in rats. Brain Research 2009, 1286:201-207. [Epub 2009 Jun 25].
Akcali D., Sayin A., Sara Y., Bolay H. Does single cortical spreading depression elicit pain behaviour in freely moving rats?. Cephalalgia 2010, 30:1195-1206. [Epub 2010 Mar 31].
Bures J., Bohdanecky Z., Weiss T. Physostigmine induced hippocampal theta activity and learning in rats. Psychopharmacologia 1962, 3:254-263.
Monmaur P., Sharif A., M'Harzi M. Involvement of septal muscarinic receptors in cholinergically mediated changes in rat rearing activity. Pharmacology Biochemistry and Behavior 1997, 58:577-582.
Redolat R., Perez-Martinez A., Carrasco M.C., Mesa P. Individual differences in novelty-seeking and behavioral responses to nicotine: a review of animal studies. Current Drug Abuse Reviews 2009, 2:230-242.
Rodrigues P.S., Martins-Ferreira H. Cholinergic neurotransmission in retinal spreading depression. Experimental Brain Research 1980, 38:229-236.
Brown C.E., Sweetnam D., Beange M., Nahirney P.C., Nashmi R. Alpha4* nicotinic acetylcholine receptors modulate experience-based cortical depression in the adult mouse somatosensory cortex. Journal of Neuroscience 2012, 32:1207-1219.
Schoenen J., Jacquy J., Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998, 50:466-470.
Cao B.J., Peng N.A. Magnesium valproate attenuates hyperactivity induced by dexamphetamine-chlordiazepoxide mixture in rodents. European Journal of Pharmacology 1993, 237:177-181.
Herzog C.J., Miot S., Mansuy I.M., Giros B., Tzavara E.T. Chronic valproate normalizes behavior in mice overexpressing calcineurin. European Journal of Pharmacology 2008, 580:153-160. [Epub 2007 Oct 25].
Flaisher-Grinberg S., Einat H. A possible utilization of the mice forced swim test for modeling manic-like increase in vigor and goal-directed behavior. Journal of Pharmacological and Toxicological Methods 2009, 59:141-145. [Epub 2009 Mar 31].
Kuruvilla A., Uretsky N.J. Effect of sodium valproate on motor function regulated by the activation of GABA receptors. Psychopharmacology (Berl) 1981, 72:167-172.
Ralph-Williams R.J., Paulus M.P., Zhuang X., Hen R., Geyer M.A. Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biological Psychiatry 2003, 53:352-359.
Oedegaard K.J., Neckelmann D., Mykletun A., Dahl A.A., Zwart J.A., Hagen K., et al. Migraine with and without aura: association with depression and anxiety disorder in a population-based study. The HUNT Study. Cephalalgia 2006, 26:1-6.
Peroutka S.J., Price S.C., Wilhoit T.L., Jones K.W. Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. Molecular Medicine 1998, 4:14-21.
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