AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
[en] Extracellular Ca(2+) is essential for the development of stable epithelial tight junctions. We find that in the absence of extracellular Ca(2+), AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase (GSK)-3beta inhibition independently induce the localization of epithelial tight junction components to the plasma membrane. The Ca(2+)-independent deposition of junctional proteins induced by AMPK activation and GSK-3beta inhibition is independent of E-cadherin. Furthermore, the nectin-afadin system is required for the deposition of tight junction components induced by AMPK activation, but it is not required for that induced by GSK-3beta inhibition. Phosphorylation studies demonstrate that afadin is a substrate for AMPK. These data demonstrate that two kinases involved in regulating cell growth and metabolism act through distinct pathways to influence the deposition of the components of epithelial tight junctions.
Zhang, Lihong ; Université de Liège - ULiège > Département Argenco : Secteur MS2F > Adéquat. struct. aux exig. de fonct.& perfor. techn.-écon.
JOURET, François ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Rinehart, Jesse
Sfakianos, Jeff
Mellman, Ira
Lifton, Richard P.
Young, Lawrence H.
Caplan, Michael J.
Language :
English
Title :
AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
Publication date :
2011
Journal title :
Journal of Biological Chemistry
ISSN :
0021-9258
eISSN :
1083-351X
Publisher :
American Society for Biochemistry and Molecular Biology, United States - Maryland
Van Itallie, C. M., and Anderson, J. M. (2004) Physiology 19, 331-338
Cereijido, M., Meza, I., and Martínez-Palomo, A. (1981) Am. J. Physiol. 240, C96-C102
Gonzalez-Mariscal, L., Chávez de Ramírez, B., and Cereijido, M. (1985) J. Membr. Biol. 86, 113-125
Martinez-Palomo, A., Meza, I., Beaty, G., and Cereijido, M. (1980) J. Cell Biol. 87, 736-745
Galli, P., Brenna, A., Camilli de, P., and Meldolesi, J. (1976) Exp. Cell Res. 99, 178-183
Hays, R. M., Singer, B., and Malamed, S. (1965) J. Cell Biol. 25, (suppl.) 195-208
Meldolesi, J., Castiglioni, G., Parma, R., Nassivera, N., and De Camilli, P. (1978) J. Cell Biol. 79, 156-172
Palant, C. E., Duffey, M. E., Mookerjee, B. K., Ho, S., and Bentzel, C. J. (1983) Am. J. Physiol. 245, C203-C212
Pitelka, D. R., and Taggart, B. N. (1983) J. Cell Biol. 96, 606-612
Sedar, A. W., and Forte, J. G. (1964) J. Cell Biol. 22, 173-188
Gumbiner, B. (1988) Trends Biochem. Sci. 13, 75-76
Boller, K., Vestweber, D., and Kemler, R. (1985) J. Cell Biol. 100, 327-332
Birchmeier, C., and Birchmeier, W. (1993) Annu. Rev. Cell Biol. 9, 511-540
Marrs, J. A., Andersson-Fisone, C., Jeong, M. C., Cohen-Gould, L., Zurzolo, C., Nabi, I. R., Rodriguez-Boulan, E., and Nelson, W. J. (1995) J. Cell Biol. 129, 507-519
McNeill, H., Ozawa, M., Kemler, R., and Nelson, W. J. (1990) Cell 62, 309-316
Rodriguez-Boulan, E., and Nelson, W. J. (1989) Science 245, 718-725
Takeichi, M. (1990) Annu. Rev. Biochem. 59, 237-252
Ringwald, M., Schuh, R., Vestweber, D., Eistetter, H., Lottspeich, F., Engel, J., Dölz, R., Jähnig, F., Epplen, J., and Mayer, S., (1987) EMBO J. 6, 3647-3653
Gumbiner, B., and Simons, K. (1986) J. Cell Biol. 102, 457-468
Capaldo, C. T., and Macara, I. G. (2007) Mol. Biol. Cell 18, 189-200
Huber, A. H., and Weis, W. I. (2001) Cell 105, 391-402
Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R., and Hoschuetzky, H. (1994) J. Cell Sci. 107, 3655-3663
Pokutta, S., and Weis, W. I. (2000) Mol. Cell 5, 533-543
Pokutta, S., Drees, F., Takai, Y., Nelson, W. J., and Weis, W. I. (2002) J. Biol. Chem. 277, 18868-18874
Rimm, D. L., Koslov, E. R., Kebriaei, P., Cianci, C. D., and Morrow, J. S. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8813-8817
Takai, Y., and Nakanishi, H. (2003) J. Cell Sci. 116, 17-27
Reymond, N., Borg, J. P., Lecocq, E., Adelaide, J., Campadelli-Fiume, G., Dubreuil, P., and Lopez, M. (2000) Gene 255, 347-355
Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto, T., Matsuda, Y., Tsukita, S., and Takai, Y. (1997) J. Cell Biol. 139, 517-528
Yamada, A., Fujita, N., Sato, T., Okamoto, R., Ooshio, T., Hirota, T., Morimoto, K., Irie, K., and Takai, Y. (2006) Oncogene 25, 5085-5102
Brakeman, P. R., Liu, K. D., Shimizu, K., Takai, Y., and Mostov, K. E. (2009) Am. J. Physiol. Renal Physiol. 296, F564-F574
Itoh, M., Nagafuchi, A., Moroi, S., and Tsukita, S. (1997) J. Cell Biol. 138, 181-192
Yamamoto, T., Harada, N., Kano, K., Taya, S., Canaani, E., Matsuura, Y., Mizoguchi, A., Ide, C., and Kaibuchi, K. (1997) J. Cell Biol. 139, 785-795
Rajasekaran, A. K., Hojo, M., Huima, T., and Rodriguez-Boulan, E. (1996) J. Cell Biol. 132, 451-463
Zhang, L., Li, J., Young, L. H., and Caplan, M. J. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 17272-17277
Hardie, D. G. (2007) Nat. Rev. Mol. Cell Biol. 8, 774-785
Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., and Hardie, D. G. (2003) J. Biol. 2, 28
Hong, S. P., Leiper, F. C., Woods, A., Carling, D., and Carlson, M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8839-8843
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., and Carling, D. (2003) Curr. Biol. 13, 2004-2008
Baas, A. F., Kuipers, J., van der Wel, N. N., Batlle, E., Koerten, H. K., Peters, P. J., and Clevers, H. C. (2004) Cell 116, 457-466
Barnes, A. P., Lilley, B. N., Pan, Y. A., Plummer, L. J., Powell, A. W., Raines, A. N., Sanes, J. R., and Polleux, F. (2007) Cell 129, 549-563
Shelly, M., Cancedda, L., Heilshorn, S., Sumbre, G., and Poo, M. M. (2007) Cell 129, 565-577
Craig, A. M., and Banker, G. (1994) Annu. Rev. Neurosci. 17, 267-310
Jiang, H., Guo, W., Liang, X., and Rao, Y. (2005) Cell 120, 123-135
Embi, N., Rylatt, D. B., and Cohen, P. (1980) Eur. J. Biochem. 107, 519-527
Woodgett, J. R. (1990) EMBO J. 9, 2431-2438
Doble, B. W., and Woodgett, J. R. (2003) J. Cell Sci. 116, 1175-1186
Etienne-Manneville, S., and Hall, A. (2003) Nature 421, 753-756
Chen, X., and Macara, I. G. (2006) Methods Enzymol. 406, 362-374
Cereijido, M., Robbins, E. S., Dolan, W. J., Rotunno, C. A., and Sabatini, D. D. (1978) J. Cell Biol. 77, 853-880
Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002) Cell 108, 837-847
Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Nature 378, 785-789
Klein, P. S., and Melton, D. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 8455-8459
Tsukamoto, T., and Nigam, S. K. (1999) Am. J. Physiol. 276, F737-F750
Lee, J. H., Koh, H., Kim, M., Kim, Y., Lee, S. Y., Karess, R. E., Lee, S. H., Shong, M., Kim, J. M., Kim, J., and Chung, J. (2007) Nature 447, 1017-1020
Mirouse, V., Swick, L. L., Kazgan, N., St Johnston, D., and Brenman, J. E. (2007) J. Cell Biol. 177, 387-392
Adams, C. L., Chen, Y. T., Smith, S. J., and Nelson, W. J. (1998) J. Cell Biol. 142, 1105-1119
Vleminckx, K., and Kemler, R. (1999) BioEssays 21, 211-220
Yonemura, S., Itoh, M., Nagafuchi, A., and Tsukita, S. (1995) J. Cell Sci. 108, 127-142
Etienne-Manneville, S., and Hall, A. (2003) Curr. Opin. Cell Biol. 15, 67-72