Reference : VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis bu...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis.
Koch, M. [> >]
Dettori, D. [> >]
Van Nuffelen, A. [> >]
Souffreau, J. [> >]
Marconcini, L. [> >]
Wallays, G. [> >]
Moons, L. [> >]
Bruyere, Françoise [> >]
Oliviero, S. [> >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Carmeliet, P. [> >]
Dewerchin, M. [> >]
Journal of Pathology (The)
John Wiley & Sons, Inc
Yes (verified by ORBi)
United Kingdom
[en] VEGF-D ; lymphatic ; gene targeting ; pathology ; mouse ; wound healing ; tumour metastasis ; myocardial infarction
[en] Vascular endothelial growth factor-D (VEGF-D) is one of the two ligands of the VEGFR-3 receptor on lymphatic endothelial cells. Gene-silencing studies in mice and Xenopus tadpoles recently showed that the role of endogenous VEGF-D in lymphatic development is moderate. By contrast, exogenous VEGF-D is capable of stimulating lymphangiogenesis. Nonetheless, its endogenous role in pathological conditions remains largely unknown. Hence, we reassessed its role in disease, using Vegf-dnull mice. Vegf-dnull mice were generated that, under physiological conditions, displayed normal embryonic and postnatal lymphangiogenesis and lymphatic remodelling, efficient lymphatic functioning and normal health. Vegf-dnull mice also reponded normally in models of skin wound healing and healing of infarcted myocardium, despite enhanced expression of VEGF-D in these models in wild-type mice. In contrast, Vegf-dnull mice displayed reduced peritumoral lymphangiogenesis and lymph node metastasis in an orthotopic pancreatic tumour model. Together, our data indicate that endogenous VEGF-D in mice is dispensible for lymphangiogenesis during development, in postnatal and adult physiology and in several pathological conditions, but significantly contributes to lymphatic metastasis.
FP7 ; 201279 - MICROENVIMET - Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network.

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