Reference : Extended-spectrum β-lactamase-producing Enterobacteriaceae in Cameroonian hospitals
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Immunology & infectious disease
Human health sciences : Public health, health care sciences & services
Life sciences : Microbiology
Extended-spectrum β-lactamase-producing Enterobacteriaceae in Cameroonian hospitals
Lonchel, Carine Magoué mailto [Université de Liège - ULiège > > Microbiologie médicale > Doctorat >]
MELIN, Pierrette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
Gangoué-Piéboji, Joseph [Institute of Medical Research and Medicinal Plant Studies, CRPMT, Yaounde, Cameroon > > > >]
Assoumou, Marie-Claire [University of Yaounde I, Yaounde, Cameroon > Department of Virology, Faculty of Medicine and Biomedical Sciences > > >]
BOREUX, Raphaël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Microbiologie médicale >]
De Mol, Patrick mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Yes (verified by ORBi)
[en] ESBL ; Cameroon ; Enterobacteriaceae ; Hospital
[en] Abstract Extended-spectrum β-lactamase (ESBL)-produc- ing Enterobacteriaceae have been described worldwide, but there are few reports on the carriage of these bacteria in Cameroon. In order to investigate the types of ESBLs and to analyse some risk factors associated with ESBL carriage, faecal samples were collected between 3 January and 3 April 2009 from hospitalised patients at Yaounde Central Hospital and at two hospitals in Ngaoundere, Cameroon. Enterobacterial isolates resistant to third-generation cepha- losporins were screened for ESBL production using the double-disk synergy test. Polymerase chain reaction (PCR) and DNA sequencing were performed in order to find out the different types of ESBL genes in presumptive ESBL- positive isolates. During the study period, a total of 121 different patients were screened for ESBL carriage. The prevalence among these patients whose faecal samples were found to contain ESBL-producers was 55.3 % (67/121). According to a univariate analysis, hospitalisation during the previous year was found to be associated with ESBL carriage. Of the 71 bacteria isolated, Escherichia coli was predominant and represented 48 % of all isolates. ESBL characterisation revealed two types of ESBLs, CTX-M-15 (96 %) and SHV-12 (4 %). The present study emphasises the importance of screening for ESBLs in laboratories in Afri- can countries. The monitoring and detection of ESBL- producing bacteria are important in the setting up of appro- priate treatment of patients and to ensure effective infection control efforts.
Researchers ; Professionals

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