[en] The goal of this study was to explore in patients with Alzheimer's disease (AD) the brain correlates of free and cued recall performance using an adaptation of the procedure developed by Grober and Buschke (1987). This procedure, which ensures semantic processing and coordinates encoding and retrieval, has been shown to be very sensitive to an early diagnosis of AD. Statistical parametric mapping (SPM 99) was used to establish clinicometabolic correlations between performance at free and cued verbal recall and resting brain metabolism in 31 patients with AD. Results showed that patient's score on free recall correlated with metabolic activity in right frontal regions (BA 10 and BA 45), suggesting that performance reflected a strategic retrieval attempt. Poor retrieval performance was tentatively attributed to a loss of functional correlation between frontal and medial temporal regions in patients with AD compared with elderly controls. Performance on cued recall was correlated to residual metabolic activity in bilateral parahippocampal regions (BA 36), suggesting that performance reflected retrieval of semantic associations, without recollection in AD. In conclusion, this study demonstrates that the diagnostic sensitivity for Alzheimer's disease of the cued recall performance in the Grober and Buschke procedure (1987) depends on the activity of parahippocampal regions, one of the earliest targets of the disease. Moreover, the results suggest that the poor performance of patients with AD during free and cued recall is related to a decreased connectivity between parahippocampal regions and frontal areas.
Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Chicherio, C.
Collette, Fabienne ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Moonen, Gustave ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Brain correlates of performance in a free/cued recall task with semantic encoding in Alzheimer disease
Publication date :
2003
Journal title :
Alzheimer Disease and Associated Disorders
ISSN :
0893-0341
eISSN :
1546-4156
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Azari NP, Rapoport SI, Grady CL, et al. Patterns of interregional correlations of cerebral glucose metabolic rates in patients with dementia of the Alzheimer type. Neurodegeneration 1992;1:101-1.
Bäckman L, Small BJ. Influences of cognitive support on episodic remembering: tracing the process from normal aging to Alzheimer's disease. Psychol Aging 1998;13:267-76.
Bäckman L, Andersson JLR, Nyberg L, et al. Brain regions associated with episodic retrieval in normal aging and Alzheimer's disease. Neurology 1999;52:1861-70.
Becker JT, Boller F, Lopez OL, et al. Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease. Cortex 1987; 23:59-72.
Becker JT, Mintun MD, Aleva K, et al. Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease. Neurology 1996;46:692-700.
Bird M, Luszcz M. Encoding specificity, depth of processing, and cued recall in Alzheimer's disease. J Clin Exp Neuropsychol 1991;13: 508-20.
Branconnier RJ, Cole JO, Spera KF, et al. Recall and recognition as diagnostic indices of malignant memory loss in senile dementia: a bayesian analysis. Exp Aging Res 1982;8:189-93.
Buckner RL, Petersen SE, Ojemann JG, et al. Functional anatomic studies of explicit and implicit memory retrieval tasks. J Neurosci 1995;15:12-29.
Buschke G, Sliwinski M, Kuslansky G, et al. Aging, encoding specificity, and memory change in the Double Memory Test. J Int Neuropsychol Soc 1995;1:483-93.
Buschke H, Sliwinski MJ, Kuslansky G, et al. Diagnosis of early dementia by the double memory test: encoding specificity improves diagnostic sensitivity and specificity. Neurology 1997;48:989-97.
Cabeza R, Kapur S, Craik FIM, et al. Functional neuroanatomy of recall and recognition: a PET study of episodic memory. J Cogn Neurosci 1997;9:277-88.
Cabeza R, Nyberg L. Imaging cognition: an empirical review of PET studies with normal subjects. J Cogn Neurosci 1997;9:1-26.
Cardebat D, Démonet J-F, Puel M, et al. Brain correlates of memory processes in patients with dementia of Alzheimer's type: a SPECT activation study. J Cereb Blood Flow Metab 1998;18:457-62.
Christensen H, Kopelman MD, Stanhope N, et al. Rates of forgetting in Alzheimer dementia. Neuropsychologia 1998;36:547-57.
Damasio AR, Van Hoesen GW, Hyman BT. Reflections on the selectivity of neuropathologic changes in Alzheimer's disease. In: Schwartz MN, ed. Modular Deficits in Alzheimer Type Dementia. Cambridge: MIT Press, 1990;83-100.
Desgranges B, Baron J-C, Eustache F. The functional neuroanatomy of episodic memory: the role of the frontal lobes, the hippocampal formation, and other areas. Neuroimage 1998a;8:198-213.
Desgranges B, Baron JC, de la Sayette V, et al. The neural substrates of memory systems impairment in Alzheimer's disease. Brain 1998b;121:611-31.
De Toledo-Morrell L, Dickerson B, Sullivan MP, et al. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease. Hippocampus 2000;10:136-42.
Deweer B, Lehericy S, Pillon B, et al. Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry 1995;58:590-97.
Eustache F, Desgranges B, Giffard B, et al. Entorhinal cortex disruption causes memory deficit in early Alzheimer's disease as shown by PET. Neuroreport 2001;12:683-5.
Fletcher PC, Shallice T, Frith CD, et al. The functional roles of prefrontal cortex in episodic memory: II. Retrieval. Brain 1998;121: 1249-56.
Folstein MF, Folstein SE, McHugh PR. Mini Mental State: a practical method for grading the cognitive state of patients for the clinicians. J Psychiatry Res 1975;12;189-98.
Fox NC, Warrington EK, Freeborough PA. Presymptomatic hippocampal atrophy in Alzheimer's disease: a longitudinal MRI study. Brain 1996;119:2001-7.
Fox NC, Warrington EK, Seiffer AL, et al. Presymptomatic cognitive deficits in individuals at risk for familial Alzheimer's disease: a longitudinal prospective study. Brain 1998;121:1631-9.
Frackowiak RSJ, Friston KJ, Frith CD, et al. Human Brain Function. San Diego: Academic Press, 1997.
Grady CL, McIntosh AR, Horwitz B, et al. Age-related reductions on human recognition memory due to impaired encoding. Science 1995; 269:218-21.
Grasby PM, Frith CD, Friston KJ, et al. A graded task approach to the functional mapping of brain areas implicated in auditory-verbal memory. Brain 1993;117:1271-82.
Grober E, Buschke H. Genuine memory deficits in dementia. Dev Neuropsychol 1987;3:13-36.
Grober E, Buschke H, Crystal H, et al. Screening for dementia by memory testing. Neurology 1988;38:900-3.
Grober E, Lipton RB, Hall C, et al. Memory impairment on free and cued selective reminding predicts dementia. Neurology 2000;54: 827-32.
Heckers S, Rauch SL, Goff D, et al. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat Neurosci 1998;1:318-23.
Helkala EL, Laulumaa V, Soininen H, et al. Recall and recognition memory in patients with Alzheimer's disease and Parkinson's disease. Ann Neurol 1988;24:214-7.
Herbster AN, Nichols T, Wiseman MB, et al. Functional connectivity in auditory-verbal short-term memory in Alzheimer's disease. Neuroimage 1996;4:67-77.
Horwitz B, Grady CL, Sclageter NL, et al. Intercorrelations of regional glucose metabolic rates in Alzheimer's disease. Brain Res 1987;407: 294-306.
Hyman BT, Van Hoesen GW, Damasio AR, et al. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984;225:1168-70.
Jetter W, Poser U, Freeman RB, et al. A verbal long term memory deficit in frontal lobe damaged patients. Cortex 1986;22:229-42.
Köhler S, Black SE, Sinden M, et al. Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. Neuropsychologia 1998;36: 901-14.
Koivisto M, Portin R, Seinelä A, et al. Automatic influences of memory in Alzheimer's disease. Cortex 1998;3:209-19.
Kopelman MD. Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia 1985;23:623-38.
Laakso MP, Soininen H, Partanen K, et al. MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity and analysis of the incorrectly classified subjects. Neurobiol Aging 1998;19:23-31.
Lepage M, Ghaffar O, Nyberg L, et al. Prefrontal cortex and episodic memory retrieval mode. Proc Natl Acad Sci USA 2000;97:506-11.
Leuchter AF, Newton TF, Cook IA, et al. Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. Brain 1992;115:1543-61.
McIntosh AR, Nyberg L, Bookstein FL, et al. Differential functional connectivity of prefrontal and medial temporal cortices during episodic memory retrieval. Hum Brain Mapp 1997;5:323-7.
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspice of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44.
Mishkin M, Vargha-Khadem F, Gadian DG. Amnesia and the organization of the hippocampal system. Hippocampus 1998;8:212-16.
Money EA, Kirk RC, McNaughton N. Alzheimer's dementia produces a loss of discrimination but no increase in rate of memory decay in delayed matching to sample. Neuropsychologia 1992;30:133-43.
Morris RG. The Cognitive Neuropsychology of Alzheimer-Type Dementia. New York: Oxford Univerisity Press, 1996.
Moscovitch M. La mémoire et le travail avec la mémoire: evaluation d'un modèle en composantes de traitement et comparaisons avec d'autres modèles. In: Schacter DL, Tulving E, eds. Systèmes de mémoire chez l'animal et chez l'homme. Marseille: Solal, 1996:265-304.
Nolde SF, Johnson MK, Raye CR. The role of prefrontal cortex during tests of episodic memory. Trends Cogn Sci 1998;2:399-406.
Nyberg L, McIntosh AR, Houle S, et al. Activation of medial temporal structures during episodic memory retrieval. Nature 1996;380:715-7.
Nyberg L, Persson J, Habib R, et al. Large scale neurocognitive networks underlying episodic memory. J Cogn Neurosci 2000;12:163-73.
Petersen RC, Smith GE, Ivrik RJ, et al. Memory function in very early Alzheimer's disease. Neurology 1994;44:867-72.
Petrides M, Alivisatos B, Evans AC. Functional activation of the human ventrolateral frontal cortex during mnemonic retrieval of verbal information. Proc Natl Acad Sci USA 1995;92:5803-7.
Pillon B, Deweer B, Agid Y, et al. Explicit memory in Alzheimer's, Huntington's and Parkinson's disease. Arch Neurol 1993;50:374-9.
Reed JM, Squire LR. Impaired recognition memory in patients with lesions limited to the hippocampal formation. Behav Neurosci 1997; 111:667-75.
Ricci PT, Zelkowicz BJ, Nebes RD, et al. Functional neuroanatomy of semantic memory: recognition of semantic associations. Neuroimage 1999;9:88-96.
Schacter DL, Alpert NM, Savage CR, et al. Conscious recollection and the human hippocampal formation: evidence from positron emission tomography. Proc Natl Acad Sci USA 1996;93:321-5.
Signorini M, Paulesu E, Friston K, et al. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative (18F)FDG PET: a clinical validation of statistical parametric mapping. Neuroimage 1999;9:63-80.
Small BJ, Herlitz A, Fratiglioni L, et al. Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study. Neuropsychology 1997;11:413-20.
Squire LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 1992;99:195-231.
Squire LR, Ojemann JG, Miezin FM, et al. Activation of the hippocampus in normal humans: a functional anatomic study of memory. Proc Natl Acad Sci USA 1992;89:1837-41.
Stern CE, Corkin S, Gonzalez RG, et al. The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci USA 1996;93: 8660-5.
Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System. An Approach to Cerebral Imaging. Stuttgart: Thieme, 1988.
Tounsi H, Deweer B, Ergis AM, et al. Sensitivity to semantic cueing: an index of episodic memory dysfunction in early Alzheimer disease. Alzheimer Dis Assoc Disord 1999;13:38-46.
Tröster AI, Jacobs D, Butters N. et al. Differentiation of Alzheimer's disease from Huntington's disease with the Wechsler Memory Scale-Revised. Clin Geriatr Med 1989;5:611-32.
Tulving E, Thomson DM. Encoding specificity and retrieval processes in episodic memory. Psychol Rev 1973;80:352-72.
Tulving E, Markowitsch HJ. Episodic and declarative memory: role of the hippocampus. Hippocampus 1998;8:198-204.
Tulving E, Kapur S, Markowitsch HJ, et al. Neuroanatomic correlates of retrieval in episodic memory: auditory sentence recognition. Proc Natl Acad Sci USA 1994;91:2012-5.
Tuokko H, Vernon-Wilkinson R, Weir J, et al. Cued recall and early identification of dementia. J Clin Exp Neuropsychol 1991;13:871-9.
Vandenberghe R, Price CJ, Wise R, et al. A common semantic system for words and pictures: functional anatomy. Nature 1996;383:254-6.
Van der Linden M, Coyette F, Wyns C, et al. L'évaluation des troubles de la mémoire verbale: élaboration et étalonnage de quatre épreuves. In: Van der Linden M, Deweer B, Coyette F, et al., eds. Marseille: Solal. In press.
Van Hoesen GW, Hyman BT, Damasio AR. Entorhinal cortex pathology in Alzheimer's disease. Hippocampus 1991;1:1-8.
Vargha-Khadem F, Gadian DG, Watkins KE, et al. Differential effects of early hippocampal pathology on episodic and semantic memory. Science 1997;277:376-80.
Welsh K, Butters N, Hughes J, et al. Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychologic measures. Arch Neurol 1991;48:278-81.
Wheeler MA, Stuss DT, Tulving E. Frontal lobe damage produces episodic memory impairment. J Int Neuropsychol Soc 1995;1:525-36.
Wiggs CL, Weisberg J, Martin A. Neural correlates of semantic and episodic memory retrieval. Neuropsychologia 1999;37:103-18.
Wilson RS, Fox JH, Kramer RL, et al. Word frequency effect and recognition memory in dementia of the Alzheimer type. J Clin Neuropsychol 1983;5:97-104.
Yonelinas AP, Hopfinger JB, Buonocore MH, et al. Hippocampal, parahippocampal and occipito-temporal contributions to associative and item recognition memory: annn fMRI study. Neuroreport 2001; 12:359-63.
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