d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.

Joly, Laure; Rosu, Frédéric; Gabelica, Valérie

doi:10.1039/c2cc33316c

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d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.

Joly, Laure; Rosu, Frédéric; Gabelica, Valérie

2012 • In Chemical Communications, 48 (67), p. 8386-8

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https://hdl.handle.net/2268/132466

DOI
10.1039/c2cc33316c

PubMed
22798996

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2012-ChemComm_TGnT.pdf

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Keywords :

mass spectrometry; G-quadruplex; electrospray; self-assembly; mechanism

Abstract :

[en] Contrasting with the common belief that d(TG(n)T) DNA sequences would form tetramolecular G-quadruplex assemblies, mass spectrometry reveals that these sequences tend to fold into G-quadruplex trimers, dimers, and eventually monomers as the G-tract length increases. The final structure also depends on the ionic strength.

Research Center/Unit :

DER Chimie
Giga-Systems Biology and Chemical Biology - ULiège

Disciplines :

Chemistry

Author, co-author :

Joly, Laure

Rosu, Frédéric ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)

Language :

English

Title :

d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.

Publication date :

2012

Journal title :

Chemical Communications

ISSN :

1359-7345

eISSN :

1364-548X

Publisher :

Royal Society of Chemistry (RSC), United Kingdom

Volume :

Issue :

Pages :

8386-8

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 18 October 2012

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