Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis

Jaïdane, H.; Sane, F.; Hiar, R.; Goffard, A.; Gharbi, J.; Geenen, Vincent; Hober, Didier

doi:10.1111/j.1365-2249.2011.04558.x

Article (Scientific journals)

Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis

Jaïdane, H.; Sane, F.; Hiar, R. et al.

2012 • In Clinical and Experimental Immunology, 168, p. 39-46

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/131622

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10.1111/j.1365-2249.2011.04558.x

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22385235

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Keywords :

Type 1 diabetes; Thymus; Coxsackievirus

Abstract :

[en] Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune diseases is an open issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely suggested as potential inducers or aggravating factors of type 1 diabetes (T1D) pathogenesis in genetically predisposed individuals. Several pathogenic mechanisms of enterovirus-induced T1D have been suggested. One of these mechanisms is the impairment of central self-tolerance due to viral infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes are targets of infection with this virus, and several abnormalities, especially disturbance of maturation/differentiation processes, were observed.Altogether, these data suggest that CV-B infection of thymus may be involved in the pathogenesis of T1D. Further investigations are needed to explore this hypothesis.

Research Center/Unit :

GIGA - I3 Centre d'Immunologie

Disciplines :

Endocrinology, metabolism & nutrition
Immunology & infectious disease

Author, co-author :

Jaïdane, H.; Université Lille 2 CHRU > Laboratoire de Virologie EA3610

Sane, F.; Université de Lille 2 CHRU > Laboratoire de Virologie EA3610

Hiar, R.; Université de Lille 2 CHRU > Laboratoire de Virologie EA 3610

Goffard, A.; Université de Lille 2 CHRU > Laboratoire de Virologie EA3610

Gharbi, J.; Université de Monastir > Faculté de Pharmacie > Laboratoire des Maladies Transmissibles

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie

Hober, Didier; Université de Lille 2 CHRU > Laboratoire de Virologie EA3610

Language :

English

Title :

Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis

Publication date :

2012

Journal title :

Clinical and Experimental Immunology

ISSN :

0009-9104

eISSN :

1365-2249

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

168

Pages :

39-46

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 04 October 2012

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