Le diabete de type 2: voyage au coeur d'une maladie complexe.

Animals; Causality; Diabetes Mellitus, Type 2/epidemiology/etiology/genetics; Disease Susceptibility; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Models, Biological; Risk Factors

Abstract :

[en] The prevalence of type 2 diabetes is rapidly growing worldwide and this metabolic disease nowadays represents a major public health concern. Besides the effects of aging, such a progression results from the interaction of several phenomena among which (1) a rather common genetic (polygenic) predisposing pattern, (2) epigenetic mechanisms, at least partially linked to nutritional disturbances during gestation influencing fetal programming, and especially, (3) a deleterious societal environment promoting the development of obesity by giving free access to excess food (rich in calories, sucrose and lipids) and markedly limiting spontaneous physical activity, or exposing to pollutants that could exert a toxic effect on the B cell. Such an obesogenic environment, already present in young age, leads to an epidemics of "diabesity". A better knowledge of the natural history of type 2 diabetes opens perspectives for the prevention of this complex disease. When type 2 diabetes is already present, a global therapeutic approach targeting environment by the promotion of lifestyle changes and the correction of all risk factors is mandatory to reduce the incidence of complications, essentially cardiovascular diseases.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

SCHEEN, André ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Paquot, Nicolas ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Language :

French

Title :

Le diabete de type 2: voyage au coeur d'une maladie complexe.

Alternative titles :

[en] Type 2 diabetes: journey in the heart of a complex disease

Publication date :

2012

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

5-6

Pages :

326-31

Peer reviewed :

Peer reviewed

Additional URL :

http://www.rmlg.ulg.ac.be

Available on ORBi :

since 13 September 2012

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2026 (12 by ULiège)

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2192 (12 by ULiège)

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Bibliography

De Fronzo RA. - Banting Lecture. From the triumvirate to the ominous octet : a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 2009, 58, 773-795.
Féry F, Paquot N. - Etiopathogénie et physiopathologie du diabète de type 2. Rev Med Liège, 2005, 60, 361-368.
Scheen AJ, Radermecker RP, Philips JC, et al. - Le traitement du diabète de type 2 : entre insulinosensibilisateurs et insulinosécrétagogues. Rev Med Liège, 2007, 62 (numéro spécial Synthèse), 40-46.
Franks PW. - Gene x environment interactions in type 2 diabetes. Curr Diab Rep, 2011, 11, 552-561.
Scheen AJ, Junien C. - Epigénétique, interface entre environnement et gènes : rôle dans les maladies complexes. Rev Med Liège, 2012, 67, 250-257.
Hectors TL, Vanparys C, van der Ven K, et al. - Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function. Diabetologia, 2011, 54, 1273-1290.
Medici F, Hawa M, Ianari A, et al. - Concordance rate for type II diabetes mellitus in monozygotic twins: actuarial analysis. Diabetologia, 1999, 42, 146-150. (Pubitemid 29064235)
Vaag A, Poulsen P. - Twins in metabolic and diabetes research: what do they tell us? Curr Opin Clin Nutr Metab Care, 2007, 10, 591-596. (Pubitemid 47254720)
Turner RC, Hattersley AT, Shaw JT, Levy JC. - Type II diabetes : clinical aspects of molecular biological studies. Diabetes, 1995, 44, 1-10.
Bonnefond A, Froguel P, Vaxillaire M. - The emerging genetics of type 2 diabetes. Trends Mol Med, 2010, 16, 407-416.
Ling C, Groop L. - Epigenetics : a molecular link between environmental factors and type 2 diabetes. Diabetes, 2009, 58, 2718-2725.
Hales CN, Barker DJ. - Type 2 (non-insulin-dependent) diabetes mellitus : the thrifty phenotype hypothesis. Diabetologia, 1992, 35, 595-601.
Portha B, Chavey A, Movassat J. - Early-life origins of type 2 diabetes : fetal programming of the beta-cell mass. Exp Diabetes Res, 2011, 2011, 105076.
Nolan CJ, Damm P, Prentki M. - Type 2 diabetes across generations : from pathophysiology to prevention and management. Lancet, 2011, 378, 169-181.
Paquot N, De Flines J, Rorive M. - L'obésité : un modèle d'interactions complexes entre génétique et environnement. Rev Med Liège, 2012, 67, 332-336.
Scheen AJ. - Diabetes, obesity, and metabolic syndrome. In : Nutrient-drug interactions (Ed : Meckling KA), CRC Press Taylor & Francis, Boca Raton, FL, US, 2007, 1-30.
Scheen AJ. - Integrated approach to treatment and prevention. In : Pharmacotherapy of obesity. Options and alternatives (Eds : Hofbauer K.G., Keller U., Boss O.), CRC Press, Boca Raton, Florida, USA, 2004, 449-463.
Esser N, Paquot N, Scheen AJ. - «Fitness» versus «Fatness» : impacts cardio-métaboliques respectifs aux différents âges de la vie. Rev Med Liège, 2010, 65, 199-205.
Grøntved A, Hu FB. - Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality : a meta-analysis. JAMA, 2011, 305, 2448-2455.
Burr JF, Rowan CP, Jamnik VK, Riddell MC. - The role of physical activity in type 2 diabetes prevention : physiological and practical perspectives. Phys Sportsmed, 2010, 38, 72-82.
Thomas DE, Elliott EJ, Naughton GA. - Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev, 2006, 3, CD002968.
Paquot N. - Le régime alimentaire chez le patient diabétique de type 2. Rev Med Liège, 2005, 60, 391-394. (Pubitemid 40941513)
Dyson PA, Kelly T, Deakin T, et al; Diabetes UK Nutrition Working Group. - Diabetes UK evidence-based nutrition guidelines for the prevention and management of diabetes. Diabet Med, 2011, 28, 1282-1288.
Niedl L, Summerbell CD, Hooper L, et al. - Dietary advice for the prevention of type 2 diabetes mellitus in adults. Cochrane Database Syst Rev, 2008, 3, CD005102.
Nettleton JA, McKeown NM, Kanoni S, et al. - Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent : a meta-analysis of 14 cohort studies. Diabetes Care, 2010, 33, 2684-2691.
Van Cauter E, Polonsky KS, Scheen AJ. - Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev, 1997, 18, 716-738. (Pubitemid 27435542)
Knutson KL, Ryden AM, Mander BA, Van Cauter E. - Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Arch Intern Med, 2006, 166, 1768-1774. (Pubitemid 44414467)
Knutson KL, Van Cauter E, Zee P, et al. - Cross-sectional associations between measures of sleep and markers of glucose metabolism among subjects with and without diabetes : the Coronary Artery Risk Development in Young Adults (CARDIA) Sleep Study. Diabetes Care, 2011, 34, 1171-1176.
Scheen AJ, Giet D. - Rôle de l'environnement dans les maladies complexes : pollution atmosphérique et contaminants alimentaires. Rev Med Liège, 2012, 67, 226-233.
Lee DH. - Persistent organic pollutants and obesity-related metabolic dysfunction : focusing on type 2 diabetes. Epidemiol Health, 2012, 34, e2012002.
Dewalque L, Charlier C. - La fertilité masculine menacée par la présence de perturbateurs endocriniens dans l'environnement ? Rev Med Liège, 2012, 67, 243-249.
Scheen AJ, Paquot N, Jandrain B. - Comment j'explore ... le risque d'un patient d'évoluer vers un diabète de type 2. Rev Med Liège, 2002, 57, 113-115.
Buijsse B, Simmons RK, Griffin SJ, Schulze MB. -Risk assessment tools for identifying individuals at risk of developing type 2 diabetes. Epidemiol Rev, 2011, 33, 46-62.
Scheen AJ, Giet D. - Prévention du diabète de type 2: un nouveau défi de santé publique. Rev Med Liège, 2005, 60, 383-390. (Pubitemid 40941512)
Lindström J, Ilanne-Parikka P, Peltonen M, et al. - Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention : follow-up of the Finnish Diabetes Prevention Study. Lancet, 2006, 368, 1673-1679. (Pubitemid 46048554)
Diabetes Prevention Program Research Group, Knowler WC, Fowler SE, Hamman RF, et al. - 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet, 2009, 374, 1677-1686.
Uusitupa MI, Stancáková A, Peltonen M, et al. - Impact of positive family history and genetic risk variants on the incidence of diabetes : the Finnish Diabetes Prevention Study. Diabetes Care, 2011, 34, 418-423.
Hivert MF, Jablonski KA, Perreault L, et al. - Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes, 2011, 60, 1340-1348.
Scheen AJ, Bourguignon JP, Guillaume M. - L'éducation thérapeutique : une solution pour vaincre l'inertie clinique et le défaut d'observance. Rev Med Liège, 2010, 65, 250-255.
Scheen AJ, Van Gaal LF. - Le diabète de type 2 au coeur du syndrome métabolique : plaidoyer pour une prise en charge globale. Rev Med Liège, 2005, 60, 566-571. (Pubitemid 40941544)
Scheen AJ, Paquot N. - Quelle nouvelle donne pour traiter les patients diabétiques de type 2 ? Médecine des Maladies métaboliques, 2009, 3, 141-146.
Inzucchi SE, Bergenstal RM, Buse JB, et al. - Management of hyperglycaemia in type 2 diabetes : a patientcentered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia, 2012, 55, 1577-1596.