Epigenetique, interface entre environnement et genes: ro1e dans les maladies complexes.

Animals; Disease/etiology/genetics; Environment; Epigenesis, Genetic/physiology; Gene-Environment Interaction; Genes/physiology; Genetic Markers/physiology; Humans; Models, Biological

Abstract :

[en] Epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. Epigenetics is one of the major mechanisms explaining the "Developmental Origin of Health and Diseases" (DOHaD). Besides genetic background inherited from parents, which confers susceptibility to certain pathologies, epigenetic changes constitute the memory of previous events, either positive or negative, along the life cycle, including at the in utero stage. The later exposition to hostile environment may reveal such susceptibility, with the development of various pathologies, among them numerous chronic complex diseases. The demonstration of such a sequence of events has been shown for metabolic diseases as obesity, metabolic syndrome and type 2 diabetes, cardiovascular disease and cancer. In contrast to genetic predisposition, which is irreversible, epigenetic changes are potentially reversible, thus giving targets not only for prevention, but possibly also for the treatment of certain complex diseases.

Disciplines :

Genetics & genetic processes

Author, co-author :

SCHEEN, André ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Junien, C.

Language :

French

Title :

Epigenetique, interface entre environnement et genes: ro1e dans les maladies complexes.

Alternative titles :

[en] Epigenetics, interface between environment and genes: role in complex diseases

Publication date :

2012

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

5-6

Pages :

250-7

Peer reviewed :

Peer reviewed

Available on ORBi :

since 12 September 2012

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Scopus citations^®
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