Reference : Le syndrome X, a la croisee des maladies metaboliques et cardio-vasculaires.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Le syndrome X, a la croisee des maladies metaboliques et cardio-vasculaires.
[fr] Syndrome X, at the crossroads of metabolic and cardiovascular diseases
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Revue Médicale de Liège
CHU de Liège
Yes (verified by ORBi)
[en] Arteriosclerosis/etiology ; Coronary Artery Disease/etiology ; Diabetes Complications ; Endothelium, Vascular/physiopathology ; Humans ; Hypercholesterolemia/complications ; Hyperinsulinism/physiopathology ; Insulin Resistance/physiology ; Metabolic Diseases/complications/physiopathology ; Myocardial Ischemia/etiology ; Risk Factors
[en] The relationships between metabolic disorders and cardiovascular diseases are very strong. Hypercholesterolaemia and diabetes mellitus, for instance, are well-known risk factors. The multifaceted metabolic syndrome or syndrome X, originally described by Reaven in 1988, comprises several abnormalities which are associated to insulin resistance and compensatory hyperinsulinaemia. Syndrome X results in an increased vascular risk by at least two mechanisms. On the one hand, it favours atherosclerosis and is associated to angiographic lesions, especially in the coronary arteries. On the other hand, it is associated to endothelial dysfunction which may contribute to myocardial ischaemia even in presence of angiographically normal arteries, a phenomenon named also syndrome X by the cardiologists. Thus, metabolic syndrome X and cardiological syndrome X are very close and syndrome X may be considered as a crossing between metabolic disorders and cardiovascular diseases.

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