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Pharma-Clinics. Le medicament du mois. La ranitidine bismuth citrate (Pylorid).
Scheen, André
1998In Revue Médicale de Liège, 53 (1), p. 41-4
Peer reviewed
 

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Keywords :
Amoxicillin/therapeutic use; Antacids/pharmacology/therapeutic use; Anti-Bacterial Agents/pharmacology/therapeutic use; Anti-Ulcer Agents/pharmacology/therapeutic use; Bismuth/pharmacology/therapeutic use; Clarithromycin/therapeutic use; Drug Combinations; Duodenal Ulcer/drug therapy; Gastric Acid/secretion; Gastric Mucosa/drug effects; Helicobacter pylori/drug effects; Histamine H2 Antagonists/pharmacology/therapeutic use; Humans; Nitroimidazoles/therapeutic use; Penicillins/therapeutic use; Proton Pumps/antagonists & inhibitors; Ranitidine/analogs & derivatives/pharmacology/therapeutic use; Receptors, Histamine H2/drug effects; Stomach Ulcer/drug therapy
Abstract :
[en] Ranitidine bismuth citrate (Pylorid, Glaxo-Wellcome) is a novel salt of ranitidine which provides a unique combination of properties: inhibition of secretion of gastric acid by competitive antagonism of the action of histamine at the histamine H2-receptor on the gastric parietal cell, mucosal protective effects and anti-Helicobacter pylori action. Ranitidine bismuth citrate provides effective healing and symptom relief, both in duodenal ulcer disease and in gastric ulcer disease. When coprescribed with certain antibiotics (clarithromycin alone or combined with amoxicillin or nitro-imidazole), it heals ulcers, eradicates Helicobacter pylori and prevents recurrence of the disease. Several clinical studies demonstrated that ranitidine bismuth citrate is well-tolerated and has quite similar efficacy as proton pump inhibitors.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Pharma-Clinics. Le medicament du mois. La ranitidine bismuth citrate (Pylorid).
Alternative titles :
[fr] Drug clinics. The drug of the month. Ranitidine bismuth citrate (Pylorid)
Publication date :
1998
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
CHU de Liège, Liège, Belgium
Volume :
53
Issue :
1
Pages :
41-4
Peer reviewed :
Peer reviewed
Available on ORBi :
since 18 May 2009

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