Article (Scientific journals)
Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice.
Vignisse, Julie; Steinbusch, Harry W. M.; Bolkunov, Alexei et al.
2011In Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35 (2), p. 510-22
Peer Reviewed verified by ORBi
 

Files


Full Text
Published JVignisse2011Dimebon enhances hippocampus-dependent learning in both appetitive and.pdf
Publisher postprint (716.5 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Anxiety; Appetitive Behavior/drug effects; Avoidance Learning/drug effects; Drinking/drug effects; Exploratory Behavior/drug effects; Hippocampus/drug effects; Indoles/pharmacology; Learning/drug effects; Male; Maze Learning/drug effects; Memory/drug effects; Mice; Mice, Inbred C57BL; Nootropic Agents/pharmacology; Time Factors
Abstract :
[en] Pre-clinical and clinical studies on dimebon (dimebolin or latrepirdine) have demonstrated its use as a cognitive enhancer. Here, we show that dimebon administered to 3-month-old C57BL6N mice 15 min prior to training in both appetitive and inhibitory learning tasks via repeated (0.1 mg/kg) and acute (0.5 mg/kg) i.p. injections, respectively, increases memory scores. Acute treatment with dimebon was found to enhance inhibitory learning, as also shown in the step-down avoidance paradigm in 7-month-old mice. Bolus administration of dimebon did not affect the animals' locomotion, exploration or anxiety-like behaviour, with the exception of exploratory behaviour in older mice in the novel cage test. In a model of appetitive learning, a spatial version of the Y-maze, dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation, and increased the duration of drinking behaviour during training/testing procedures. Repeated treatment with dimebon did not alter the behaviours in other tests or water consumption. Acute treatment of water-deprived and non-water-deprived mice with dimebon also did not affect their water intake. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice.
Disciplines :
Neurosciences & behavior
Author, co-author :
Vignisse, Julie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Steinbusch, Harry W. M.
Bolkunov, Alexei
Nunes, Joao
Santos, Ana Isabel
Grandfils, Christian ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Bachurin, Sergei
Strekalova, Tatyana
Language :
English
Title :
Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice.
Publication date :
2011
Journal title :
Progress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN :
0278-5846
eISSN :
1878-4216
Publisher :
Elsevier Science, Oxford, United Kingdom
Special issue title :
The Neurobiology of Neurodegenerative Disorder: From Basic to Clinical Research
Volume :
35
Issue :
2
Pages :
510-22
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier B.V. All rights reserved.
Available on ORBi :
since 06 August 2012

Statistics


Number of views
26 (0 by ULiège)
Number of downloads
90 (1 by ULiège)

Scopus citations®
 
41
Scopus citations®
without self-citations
21
OpenCitations
 
35

Bibliography


Similar publications



Contact ORBi