[en] Pre-clinical and clinical studies on dimebon (dimebolin or latrepirdine) have demonstrated its use as a cognitive enhancer. Here, we show that dimebon administered to 3-month-old C57BL6N mice 15 min prior to training in both appetitive and inhibitory learning tasks via repeated (0.1 mg/kg) and acute (0.5 mg/kg) i.p. injections, respectively, increases memory scores. Acute treatment with dimebon was found to enhance inhibitory learning, as also shown in the step-down avoidance paradigm in 7-month-old mice. Bolus administration of dimebon did not affect the animals' locomotion, exploration or anxiety-like behaviour, with the exception of exploratory behaviour in older mice in the novel cage test. In a model of appetitive learning, a spatial version of the Y-maze, dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation, and increased the duration of drinking behaviour during training/testing procedures. Repeated treatment with dimebon did not alter the behaviours in other tests or water consumption. Acute treatment of water-deprived and non-water-deprived mice with dimebon also did not affect their water intake. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice.
Disciplines :
Neurosciences & behavior
Author, co-author :
Vignisse, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Steinbusch, Harry W. M.
Bolkunov, Alexei
Nunes, Joao
Santos, Ana Isabel
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Bachurin, Sergei
Strekalova, Tatyana
Language :
English
Title :
Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice.
Publication date :
2011
Journal title :
Progress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN :
0278-5846
eISSN :
1878-4216
Publisher :
Elsevier Science, Oxford, United Kingdom
Special issue title :
The Neurobiology of Neurodegenerative Disorder: From Basic to Clinical Research
Volume :
35
Issue :
2
Pages :
510-22
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier B.V. All rights reserved.
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