Fine mapping and physical characterization of two linked quantitative trait loci affecting milk fat yield in dairy cattle on BTA26.

Gautier, Mathieu; Barcelona, Rosa Roy; Fritz, Sebastien; Grohs, Cecile; Druet, Tom; Boichard, Didier; Eggen, Andre; Meuwissen, Theo H E

doi:10.1534/genetics.105.046169

Article (Scientific journals)

Fine mapping and physical characterization of two linked quantitative trait loci affecting milk fat yield in dairy cattle on BTA26.

Gautier, Mathieu; Barcelona, Rosa Roy; Fritz, Sebastien et al.

2006 • In Genetics, 172 (1), p. 425-36

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/12737

DOI
10.1534/genetics.105.046169

PubMed
16172504

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Keywords :

Animals; Cattle/genetics; Cell Membrane Permeability; Chromosome Mapping; Chromosomes, Artificial, Yeast; Female; Genotype; Lactation; Linkage (Genetics); Lipids/analysis; Microsatellite Repeats; Milk/chemistry; Milk Proteins/analysis; Phylogeny; Quantitative Trait Loci; Telomere/physiology

Abstract :

[en] Previously, a highly significant QTL affecting fat yield and protein yield and mapped to the bovine BTA26 chromosome has been reported to segregate in the French Holstein cattle population. To confirm and refine the location of this QTL, the original detection experiment was extended by adding 12 new families and genotyping 25 additional microsatellite markers (including 11 newly developed markers). Data were then analyzed by an approach combining both linkage and linkage disequilibrium information, making it possible to identify two linked QTL separated by 20 cM corresponding to approximately 29 Mb. The presence of a QTL affecting protein yield was confirmed but its position was found to be more telomeric than the two QTLunderlying fat yield. Each identified QTL affecting milk fat yield was physically mapped within a segment estimated to be <500 kb. Two strong functional candidate genes involved, respectively, in fatty acid metabolism and membrane permeability were found to be localized within this segment while other functional candidate genes were discarded. A haplotype comprising the favorable allele at each QTL position appears to be overrepresented in the artificial insemination bull population.

Disciplines :

Animal production & animal husbandry
Genetics & genetic processes

Author, co-author :

Gautier, Mathieu

Barcelona, Rosa Roy

Fritz, Sebastien

Grohs, Cecile

Druet, Tom ; Institut Scientifique de Recherche Agronomique - INRA > Département de Génétique Animale > Station de Génétique Quantitative et Appliquée

Boichard, Didier

Eggen, Andre

Meuwissen, Theo H E

Language :

English

Title :

Fine mapping and physical characterization of two linked quantitative trait loci affecting milk fat yield in dairy cattle on BTA26.

Publication date :

2006

Journal title :

Genetics

ISSN :

0016-6731

eISSN :

1943-2631

Publisher :

Genetics Society of America, Baltimore, United States - Maryland

Volume :

172

Issue :

Pages :

425-36

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 May 2010

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