Article (Scientific journals)
Gene transfer in inner ear cells: a challenging race
Sacheli, Rosalie; Delacroix, Laurence; Van Den Ackerveken, Priscilla et al.
2013In Gene Therapy, 20
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Keywords :
gene delivery; inner ear; therapy
Abstract :
[en] Recent advances in human genomics led to the identification of numerous defective genes causing deafness, which represent novel putative therapeutic targets. Future gene-based treatment of deafness resulting from genetic or acquired sensorineural hearing loss may include strategies ranging from gene therapy to antisense delivery. For successful development of gene therapies, a minimal requirement involves the engineering of appropriate gene carrier systems. Transfer of exogenous genetic material into the mammalian inner ear using viral or non-viral vectors has been characterized over the last decade. The nature of inner ear cells targeted, as well as the transgene expression level and duration, are highly dependent on the vector type, the route of administration and the strength of the promoter driving expression. This review summarizes and discusses recent advances in inner ear gene-transfer technologies aimed at examining gene function or identifying new treatment for inner ear disorders.
Disciplines :
Author, co-author :
Sacheli, Rosalie  
Delacroix, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R: Neurosciences
Van Den Ackerveken, Priscilla ;  Université de Liège - ULiège > GIGA - Neurosciences
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
Language :
Title :
Gene transfer in inner ear cells: a challenging race
Publication date :
Journal title :
Gene Therapy
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
Peer reviewed :
Peer Reviewed verified by ORBi
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since 25 June 2012


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