[en] In this paper we consider the question of parameter identifiability for biochemical reaction networks, as typically encountered in systems biology. Specifically, we are interested in deriving conditions on the biochemical reaction network and on the measured outputs that guarantee identifiability of the parameters. Taking the specific system structure of biochemical reaction networks into account, we derive sufficient conditions for local parameter identifiability based on a suitable system expansion which does not any more directly depend on the parameters. Rather, as shown, the problem of identifiability can be recast as the question of observability of the (parameter free) expanded system. The conditions derived are exemplified considering a simple example
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Farina, Marcello
Findeisen, Rolf
Bullinger, Eric ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique
Bittanti, Sergio
Allgöwer, Frank
Wellstead, Peter
Language :
English
Title :
Results towards identifiability properties of biochemical reaction networks
Publication date :
December 2006
Event name :
45th IEEE Conf. on Decision and Control
Event place :
San Diego, United States
Event date :
from 13-12-2006 to 15-12-2006
Audience :
International
Main work title :
Proc. of the 45th IEEE Conference on Decision and Control, San Diego, USA
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