Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants:  a multicentre translational study

De Luca, Daniele; Capoluongo, Ettore; Rigo, Vincent

doi:10.1186/1471-2431-11-101

Article (Scientific journals)

Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study

De Luca, Daniele; Capoluongo, Ettore; Rigo, Vincent

2011 • In BMC Pediatrics, 11 (101)

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/124479

DOI
10.1186/1471-2431-11-101

PubMed
22067747

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Keywords :

secretory phospholipase A2; surfactant catabolism; lung inflammation; newborn infant; respiratory function

Abstract :

[en] Background Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a promising therapeutic target. Preliminary data allow foreseeing the importance of such enzyme in some critical respiratory diseases in neonates and infants, as well. Our study aim is to clarify the role of sPLA2 and its modulators in the pathogenesis and clinical severity of hyaline membrane disease, infection related respiratory failure, meconium aspiration syndrome and acute respiratory distress syndrome. sPLA2 genes will also be sequenced and possible genetic involvement will be analysed. Methods/Design Multicentre, international, translational study, including several paediatric and neonatal intensive care units and one coordinating laboratory. Babies affected by the above mentioned conditions will be enrolled: broncho-alveolar lavage fluid, serum and whole blood will be obtained at definite time-points during the disease course. Several clinical, respiratory and outcome data will be recorded. Laboratory researchers who perform the bench part of the study will be blinded to the clinical data. Discussion This study, thanks to its multicenter design, will clarify the role(s) of sPLA2 and its pathway in these diseases: sPLA2 might be the crossroad between inflammation and surfactant dysfunction. This may represent a crucial target for new anti-inflammatory therapies but also a novel approach to protect surfactant or spare it, improving alveolar stability, lung mechanics and gas exchange.

Disciplines :

Pediatrics

Author, co-author :

De Luca, Daniele; University Hospital “A.Gemelli”, Catholic University of the Sacred Heart - Rome - Italy > Dept of Emergency and Intensive Care > Pediatric Intensive Care Unit

Capoluongo, Ettore; University Hospital “A.Gemelli”, Catholic University of the Sacred Heart - Rome - Italy > Dept of Molecular Medicine > Laboratory of Clinical Molecular Biology

Rigo, Vincent ; Université de Liège - ULiège > Néonatologie CHR

Language :

English

Title :

Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study

Publication date :

08 November 2011

Journal title :

BMC Pediatrics

eISSN :

1471-2431

Publisher :

BioMed Central

Volume :

Issue :

101

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.biomedcentral.com/1471-2431/11/101

Commentary :

Study protocol

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since 06 June 2012

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