No full text
Poster (Scientific congresses and symposiums)
Preparation and characterization of thermo-responsive gold nanohybrids
Liu, Ji; Hurtgen, Marie; Detrembleur, Christophe et al.
2011International Symposium on Stimuli-Responsive Materials
 

Files


Full Text
No document available.

Send to



Details



Keywords :
metal nanoparticle; stimuli-responsive polymer; temperature-responsive polymer
Abstract :
[en] Stimuli-responsive nano-materials have been playing increasingly important roles in the biomedical field due to their ability to alter the physico-chemical properties in response to external stimuli, such as temperature, pH, ionic strength, magnetic field, etc. Nanohybrids bearing an inorganic core and thermo-responsive polymer shell are particularly applicable in target delivery and controlled drug release. Poly (N-vinylcaprolactam) (PNVCL) and its copolymers, exhibiting lower critical solution temperature (LCST) where the transition between hydrophilic and hydrophobic state happens, is one of the optimal choices for this core/shell structure. Here we present the in-situ fabrication of thermo-responsive gold nanohybrids coated with a novel poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) (PVOH-b-PNVCL) block copolymer prepared by the cobalt-mediated radical polymerization (CMRP). The interaction between both PVOH and PNVCL segments and gold nanoparticles was confirmed by FT-IR spectra. A sharp thermo-induced phase transition with a good reversibility upon change in temperature was detected by DLS and UV/vis spectrometer. Furthermore, the presence of hydrophilic PVOH moieties endows the gold nanohybrids with improved colloidal stability above LCST without any flocculation detected, compared with the gold nanoparticles stabilized with PNVCL homopolymer. This kind of gold nanohybrids can be envisaged as a new drug delivery vehicle.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Liu, Ji ;  Institut de Chimie de la Matière Consensée de Bordeaux and University of Liège (ULg) > Department of Chemistry of Liège > Center for Education and Research on Macromolecules (CERM, Liège)
Hurtgen, Marie ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Detrembleur, Christophe ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Mornet, Stephan;  Institut de Chimie de la Matière Consensée de Bordeaux
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Duguet, Etienne;  Institut de Chimie de la Matière Consensée de Bordeaux
Language :
English
Title :
Preparation and characterization of thermo-responsive gold nanohybrids
Publication date :
25 October 2011
Event name :
International Symposium on Stimuli-Responsive Materials
Event organizer :
Marek Urban
Event place :
Hattiesburg, United States
Event date :
24/10/2011 - 25/10/2011
Audience :
International
Funders :
the "IDS-FUNMAT" erasmus-mundus program
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This poster was presented by Ji Liu
Available on ORBi :
since 06 June 2012

Statistics


Number of views
80 (11 by ULiège)
Number of downloads
0 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi