[en] The objective of this study was to compare the sedative and peripheral hemodynamic effects of acepromazine (ACP) and promethazine (PTZ) in the standing healthy horse. Nine healthy Warmblood horses randomly received either intravenous ACP at 0.1 mg/kg or PTZ at 0.1, 0.2, and 0.3 mg/kg. A sedation score based on clinical examination was recorded, and systolic arterial blood pressure was noninvasively evaluated using a Doppler flow detector at the tail, just before and every 15 minutes until 60 minutes after drug injection. Hemodynamics of the median artery of the left forelimb was studied using Doppler ultrasonography just before and 45 minutes after injection of the drug, which allowed calculation of surface (SURF), diameter (DIAM), and circumference (CIRC) of the vessel and peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF), and resistivity index (RI) of the blood flow. Regardless of the dose used, PTZ had lesser sedative and hypotensive effects than ACP at 0.1 mg/kg and did not induce significant variations in SURF, DIAM, CIRC, PSV, EDV, MV, VF, and RI of the studied standing horses. Conversely, the vasodilatory properties of ACP were illustrated by a significant increase in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a significant reduction of the RI. Unlike ACP, PTZ did not induce alterations on the morphology of the Doppler waveform. PTZ appears to have less sedative and peripheral vasodilator effects than ACP, thus it could be safer than ACP in patients suffering from hypotension.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Pequito, Manuel
Amory, Hélène ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Busoni, Valeria ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Imagerie médicale
de Moffarts, Brieuc
Sandersen, Charlotte ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Language :
English
Title :
Comparison of the sedative and hemodynamic effects of acepromazine and promethazine in the standing horse.
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Bibliography
Muir WW III, ed. Standing chemical restraint in horses; tranquilisers, sedatives and anagesics. In: Equine Anaesthesia. St. Louis, MO: Mosby; 1991: p. 247-80.
Leise B.S., Fugler L.A., Stokes A.M., Eades S.C., Moore R.M. Effects of intramuscular administration of acepromazine on palmar digital blood flow, palmar digital arterial pressure, transverse facial arterial pressure, and packed cell volume in clinically healthy, conscious horses. Vet Surg 2007, 36:717-723.
Mysinger P.W., Redding R.W., Vaughan J.T., Purohit R.C., Holladay J.A. Electroencephalographic patterns of clinically normal, sedated and tranquillised newborn foals and adult horses. Am J Vet Res 1985, 46:36-41.
Baldessarini R.J., Tarazi F.I. Pharmacology of psychosis and mania. Goodman and Gilman's the pharmacological basis of therapeutics 2006, 461-500. McGraw-Hill, New York, NY. 11th ed. L.L. Brunton, J.S. Lazo, K.L. Parker (Eds.).
Parry B.W., Anderson G.A., Gay C.C. Hypotension in the horse induced by acepromazinemaleate. Aust Vet J 1982, 59:148-152.
Walker M., Geiser D. Effects of acetylpromazine on the hemodynamics of the equine metatarsal artery, as determined by two-dimensional real-time and pulsed Doppler ultrasonography. Am J Vet Res 1986, 47:1075-1078.
Hall LW, Clarke KW, Trim CM, eds. Principles of sedation, analgesia and premedication. In: Veterinary Anaesthesia, 10th ed. Edinburgh, United Kingdom: WB Saunders Co; 2001: p. 75-112.
Brock N. Acepromazine revisited. Can Vet J 1994, 35:458-459.
Lerche E., Blais D., Cuvelliez S. Revue des protocoles de base d'anesthésie générale chez le cheval. Point Vét 1992, 24:25-29.
McKelvey D, Hollingshead W, eds. The preanesthetic period. In: Veterinary Anaesthesia and Analgesia, 3rd ed., St. Louis, MO: Mosby; 2003: p. 1-50.
Szöke M., Blais D., Cuvelliez S. Le point sur l'utilisation des phénothiazines chez le cheval. Le Médecin Vétérinaire du Québec 1994, 24:35-39.
Serteyn D, Deby-Dupont G, Peters F, Thierry F, Gangl M, Gülke S, et al. Comparative study of the effects of acepromazine and structuraly parent compounds on the TNF-a release by monocytes stimulated by Chlamydia Pneumoniae. In: Proceedings of the Autumn Meeting of the Association of Veterinary Anaesthetists, Heraklion, Greece, 2002:35.
Serteyn D, Deby-Dupont G, Péters F, Thierry F, Gangl M, Gülke S, et al. Acepromazine modulates the cell differentiation: in vitro experiments on monocytes stimulated by Chlamydia pneumoniae toxins. In: Proceedings of the Spring Meeting of the Association of Veterinary Anaesthetists, Uppsala, Sweden, 2001:46.
Serteyn D., Benbarek H., Deby-Dupont G., Grulke S., Caudron I., Deby C., et al. Effects of acepromazine on equine polimorphonuclear neutrophil activation: a chemiluminescence study. Vet J 1999, 157:332-335.
Serteyn D, Gangl M, Grulke S, Thierry F, Lamy M. Antilipoperoxidant properties of acepromazine. In: Proceedings of the 7th World Congress of Veterinary Anaesthesia, Berne, Switzerland; 2000:50.
Péters F., Franck T., Pequito M., de la Rebière G., Grulke S., Salccicia A., Verwilghen D., et al. In vivo administration of acepromazine or promethazine to horse decreases the reactive oxygen species production response of subsequently isolated neutrophils to stimulation with phorbol myristate acetate. J Vet Pharmacol Ther 2009, 32:541-547.
Sandersen C., Mouithys-Mickalad A., de la Rebière G., Deby G., Serteyn D., Franck T. Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils. Vet Anaesth Analg 2011, 38:83-93.
Marroum P.J., Webb A.I., Aeschbacher G., Curry S.H. Pharmacokinetics and pharmacodynamics of acepromazine in horses. Am J Vet Res 1994, 55:1428-1433.
Miller P.J., Martin I.C., Kohnke J.R. Responses of horses to acepromazine maleate administered orally in a paste. Res Vet Sci 1987, 42:318-325.
MacCrindle C.M., Edebes H., Swan G.F. The use of long-acting neuroleptics, perphenazine énanthate and pipothiazine palmitate in two horses. J S Afr Vet Assoc 1989, 60:208-209.
Baird J.D., Arroyo L.G., Vengust M., McGurrin M.K., Rodriguez-Palacios A., Kenney D.G., et al. Adverse extrapyramidal effects in four horse given fluphenazine decanoate. J Am Vet Med Assoc 2006, 229:104-110.
Steffey E.P., Kelly A.B., Farvert, Woliner M.J. Cardiovascular and respiratory effects of acetylpromazine and xylazine on halothane-anesthetized horses. J Vet Pharmacol Ther 1985, 8:290-302.
Menzies-Gow N.J. Effects of sedation with acepromazine on echocardiographic measurements in eight healthy thoroughbred horses. Vet Rec 2008, 163:21-25.
Hunt R.J., Brandon C.I., McCann M.E. Effects of acetylpromazine, xylazine, and vertical load on digital arterial blood flow in horses. Am J Vet Res 1994, 55:375-378.
Schmucker N., Schatzmann U., Budde K., Gundel M., Jäggin C.E., Meier H. Duplex-utrasonographic evaluation of the common carotid artery in the resting, sedated and anesthetised horse. Vet Radiol Ultrasound 2000, 41:168-171.
Raisis A.L., Young L.E., Blissit K.J., Brearley J.C., Meire H.B., Taylor P.M., et al. A comparison of the hemodynamic effects of isoflurane and halotane anaesthesia in horses. Equine Vet J 2000, 32:318-326.
Cochard T., Toal R.L., Saxton A.M. Doppler ultrasonographic features of thoracic limb arteries in clinically normal horses. Am J Vet Res 2000, 61:183-190.
Szatmári V., Sótonyi P., Voros K. Normal duplex doppler waveforms of major abdominal blood vessels in dogs: a review. Vet Radiol Ultrasound 2001, 42:93-107.
Schwarzwald C.C., Schober K.E., Bonagura J.D. Methods and reliability of tissue doppler imaging for assessment of left ventricular radial wall motion in horses. J Vet Intern Med 2009, 23:643-652.
Bollwein H., Weber F., Woschee I., Stolla R. Transrectal Doppler sonography of uterine and umbilical blood flow during pregnancy in mares. Theriogenology 2004, 61:499-509.
Wongaumnuaykul S., Siedler C., Schobesberger H., Stolla R. Doppler sonographic evaluation of the digital blood flow in horses with laminitis or septic pododermatitis. Vet Radiol Ultrasound 2006, 47:199-205.
Sleeper M.M., Durando M.M., Miller M., Habecker P.L., Reef V.B. Aortic root disease in four horses. J Am Vet Med Assoc 2001, 219:491-496.
Guglielmini C., Bernardini D. Echo-Doppler findings of a carotid-jugular fistula in a foal. Vet Radiol Ultrasound 2003, 44:310-314.
Duggan V.E., Holbrook T.C., Dechant J.E., Blaik M.A., Ritchey J.W. Diagnosis of aorto-iliac thrombosis in a quarter horse foal using Doppler ultrasound and nuclear scintigraphy. J Vet Intern Med 2004, 18:753-756.
Lightowler C., Guglielmini C., Pidal G., Chiaramonte P. Doppler-derived evidence of severe pulmonary arterial hypertension in a pony with recurrent airway obstruction. Vet Rec 2009, 164:340-341.
Moore R.M., Hardy J., Muir W.W. Mural blood flow distribution in the large colon of horses during low-flow ischemia and reperfusion. Am J Vet Res 1995, 56:812-818.
Wilkins P.A., Ducharme N.G., Lowe J.E., Schwark W.S., Meschter C., Erb H.N. Measurements of blood flow and xantine oxidase activity during postischemic reperfusion of the large colon of ponies. Am J Vet Res 1994, 55:1168-1177.
Adair H.S., Globe D.O., Schmidhammer J.L., Shires G.M. Laminar micro vascular flow, measured by means of laser Doppler flowmetry, during the podromal stages of black walnut-induced laminitis in horse. Am J Vet Res 2000, 61:862-868.
Kristoffersen M., Ohberg L., Johnston C., Alfredson H. Neovascularisation in chronic tendon injuries detected with colour Doppler ultrasound in horse and man: implications for research and treatment. Knee Surg Sports Traumatol Arthrosc 2005, 13:505-508.
Cipone M., Pietra M., Gandini G., Boari A., Guglielmini C., Venturoli M. Pulsed wave Doppler ultrasonographic evaluation of the common carotid artery in the resting horse: physiologic data. Vet Radiol Ultrasound 1997, 38:200-206.
Pietra M., Guglielmini C., Nardi S., Gandini G., Cipone M. Influence of weight bearing and hoof position on Doppler evaluation of lateral palmar digital arteries in healthy horses. Am J Vet Res 2004, 65:1211-1215.
Menzies-Gow N.J., Marr C.M. Repeatability of doppler ultrasonographic measurement of equine digital blood flow. Vet Radiol Ultrasound 2007, 48:281-285.
Hoffman K.L., Wood A.K., Kirby A.C. Use of Doppler ultrasonography to evaluate renal arterial blood flow in horses. Am J Vet Res 1997, 58:697-701.
Pozor M.A., McDonnell S.M. Color Doppler ultrasound evaluation of testicular blood flow in stallions. Theriogenology 2004, 61:799-810.
Gilhooly M.H., Eades S.C., Stokes A.M., Moore R.M. Effects of topical nitroglycerine patches and ointment on digital venous plasma nitric oxide concentrations and digital blood flow in healthy conscious horses. Vet Surg 2005, 34:604-609.
Schwarzwald C.C., Bonagura J.D., Luis-Fuentes V. Effects of diltiazem on hemodynamic variables and ventricular function in healthy horses. J Vet Intern Med 2005, 19:703-711.
Raisis A.L., Yong L.E., Blissit K.J., Walsh K., Meire H.B., Taylor P.M., et al. Effect of a 30 minute infusion of dobutamine hydrochloride on hindlimb blood flow and hemodynamics in halothane-anaesthetised horses. Am J Vet Res 2000, 51:1282-1288.
Raisis A.L., Young E.L., Meire H.B., Taylor P.M., Blissitt K.J., Marlin D., et al. Measurements of hindlimb blood fow recorded using Doppler ultrasound during administration of vasoactive agents in halothane-anesthetized horses. Vet Radiol Ultrasound 2000, 41:64-72.
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