Article (Scientific journals)
Evaluation of saliva as an alternative matrix for monitoring plasma Zidovudine, Lamivudine and nevirapine concentrations in Rwanda
Gras, Alain; Schneider, Serge; Karasi, Jean Claude et al.
2011In Current HIV Research, 9 (4), p. 223-8
Peer Reviewed verified by ORBi
 

Files


Full Text
Gras A, Arendt V_Current HIV Research Vol9 No4 223-228 2011.pdf
Publisher postprint (645.52 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Saliva may provide interesting advantages as matrix for compliance measurements, pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We investigated the feasibility of using saliva for compliance monitoring of zidovudine (ZDV), lamivudine (3TC) and nevirapine (NVP) in 29 HIV-1 infected patients from Rwanda. ZDV, 3TC and NVP drug levels were quantified by an LC/MS-MS method in plasma and stimulated saliva samples and compared using Bland-Altman analysis. Seven patients demonstrated undetectable saliva ZDV levels while five out of these seven also showed no 3TC salivary concentrations. For the other samples, we observed a good agreement between salivary and plasma concentrations of each antiretroviral drug. A significant relation between the difference in saliva and plasma ZDV concentrations and the average ZDV concentration in the two matrices was deduced as follow: y = -380.15 + 1.79 x. The log saliva and plasma concentration difference of both 3TC and NVP was consistent across the range of average log concentration. Overall, we showed large agreement limits suggesting a wide inter patient variability that may result to non-reliable plasma level predictions from saliva drug measurements. Therefore, our results indicate that saliva may serve as a valuable tool only for NVP compliance testing because of its high salivary concentration.
Disciplines :
Biotechnology
Author, co-author :
Gras, Alain
Schneider, Serge
Karasi, Jean Claude ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Ternes, Anne-Marie
Sauvageot, Nicolas
Karasi-Omes, Christine
Henry, Anne-Pascale
Schmit, Jean-Claude
Seguin-Devaux, Carole
Arendt, Vic
Language :
English
Title :
Evaluation of saliva as an alternative matrix for monitoring plasma Zidovudine, Lamivudine and nevirapine concentrations in Rwanda
Publication date :
2011
Journal title :
Current HIV Research
ISSN :
1570-162X
eISSN :
1873-4251
Publisher :
Bentham Science Publishers Ltd.
Volume :
9
Issue :
4
Pages :
223-8
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
2011/06/16
Available on ORBi :
since 21 May 2012

Statistics


Number of views
110 (15 by ULiège)
Number of downloads
335 (7 by ULiège)

Scopus citations®
 
9
Scopus citations®
without self-citations
9
OpenCitations
 
9

Bibliography


Similar publications



Contact ORBi