Article (Scientific journals)
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
Plumier, Jean-Christophe; Krueger, A. M.; Currie, R. W. et al.
1997In Cell Stress and Chaperones, 2 (3), p. 162-7
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Keywords :
Animals; Arterial Occlusive Diseases/genetics/metabolism/pathology; Brain Ischemia/genetics/metabolism/pathology; Disease Susceptibility; HSP70 Heat-Shock Proteins/analysis/biosynthesis/genetics; Hippocampus/blood supply/pathology; Humans; Mice; Mice, Transgenic; Neurons/pathology
Abstract :
[en] Using transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral ischemia. Twenty-four hours after permanent occlusion of the middle cerebral artery, no difference in infarct area was detected between Hsp70-transgenic and non-transgenic mice. In the non-transgenic mice, many pyramidal neurons of the ipsilateral hippocampus were observed to be pyknotic. However, in all Hsp70-transgenic mice, hippocampal pyramidal neurons showed normal morphology and no evidence of pyknosis. This suggests that constitutive expression of Hsp70 reduces the extent of damage following permanent middle cerebral artery occlusion.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Plumier, Jean-Christophe ;  Dalhousie University > Anatomy and Neurobiology
Krueger, A. M.;  Dalhousie University > Anatomy and Neurobiology
Currie, R. W.;  Dalhousie University > Anatomy and Neurobiology
Kontoyiannis, D.;  Hellenic Pasteur Institute > Molecular Genetics
Kollias, G.;  Hellenic Pasteur Institute > Molecular Genetics
Pagoulatos, G. N.;  University of Ioannina Medical School > General Biology
Language :
English
Title :
Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury.
Publication date :
1997
Journal title :
Cell Stress and Chaperones
ISSN :
1355-8145
eISSN :
1466-1268
Publisher :
Cell Stress Society International, Storrs, United States - Connecticut
Volume :
2
Issue :
3
Pages :
162-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 May 2009

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