[en] Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 knockout mice. Here, we report that Hsf2(-/-) mice are viable and fertile and exhibit normal life span and behavioral functions. We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function.
McMillan, D Randy; University of Texas Southwestern Medical Center at Dallas > Internal Medicine and Pediatrics
Christians, Elisabeth; University of Texas Southwestern Medical Center at Dallas > Internal Medicine
Forster, Michael; University of Noth Texas Health Science Center at Fort Worth > Pharmacology
Xiao, XianZhong; University of Texas Southwestern Medical Center at Dallas > Internal Medicine
Connell, Patrice; Univesity of Texas Southwestern Medical Center at Dallas > Internal Medicine
Plumier, Jean-Christophe ; Massachusetts General Hospital and Harvard Medical School > Neuroscience Center > Stroke and Neurovascular Regulation
Zuo, XiaoXia; university of Texas Southwestern Medical Center at Dallas > Internal Medicine
Richardson, James; University of Texas Southwestern Medical Center at Dallas > Pathology
Morgan, Sylvia; University of Texas Southwestern Medical Center at Dallas > Internal Medicine
Benjamin, Ivor J; University of Texas Southwestern Medical Center at Dallas and University of North Texas Health Science Center at Fort Worth > Internal Medicine and Pharmacology
Language :
English
Title :
Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
Publication date :
2002
Journal title :
Molecular and Cellular Biology
ISSN :
0270-7306
eISSN :
1098-5549
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
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