Article (Scientific journals)
Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines
Warnant, Jérôme; Marcotte, N.; Reboul, J. et al.
2012In Analytical and Bioanalytical Chemistry, 403, p. 1395-1404
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Keywords :
self-assembly in solution; micelle
Abstract :
[en] The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The pH-sensitive micelles were obtained with double hydrophilic block copolymers containing a poly(acrylic acid) block linked to a modified poly(ethylene oxide) block and various polyamines (polylysine, linear and branched polyethyleneimine, polyvinylpyridine, and polyallylamine). The pH range of micellization in which both components are ionized was determined for each polyamine. The resulting PIC micelles were characterized using dynamic light scattering and smallangle X-ray scattering experiments (SAXS). The PIC micelles presented a core–corona nanostructure with variable polymer density contrasts between the core and the corona, as revealed by the analysis of the SAXS curves. It was shown that PIC micelle cores constituted by polyacrylate chains and polyamines were more or less dense depending on the nature of the polyamine. It was also determined that the density of the cores of the PIC micelles depended strongly on the nature of the polyamine. These homogeneous cores were surrounded by a large hairy corona of hydrated polyethylene oxide block chains. Auramine O (AO) was successfully entrapped in the PIC micelles, and its fluorescence properties were used to get more insight on the core properties. Fluorescence data confirmed that the cores of such micelles are quite compact and that their microviscosity depended on the nature of the polyamine. The results obtained on these core–shell micelles allow contemplating a wide range of applications in which the AO probe would be replaced by various cationic drugs or other similarly charged species to form drug nanocarriers or new functional nanodevices.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Warnant, Jérôme;  Institut Charles Gerhardt ( Montpellier, France) and University of Liège (ULg) > Department of Chemistry (Liège) > Center for Education and Research on Macromolecules (CERM, Liège)
Marcotte, N.;  Institut Charles Gerhardt, Montpellier, France
Reboul, J.;  Institut Charles Gerhardt, Montpellier, France
Layrac, G.;  Institut Charles Gerhardt, Montpellier, France
Aqil, Abdelhafid ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lerner, D. A.;  Institut Charles Gerhardt, Montpellier, France
Gérardin, C.;  Institut Charles Gerhardt, Montpellier, France
Language :
English
Title :
Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines
Publication date :
May 2012
Journal title :
Analytical and Bioanalytical Chemistry
ISSN :
1618-2642
eISSN :
1618-2650
Publisher :
Springer Science & Business Media B.V., Berlin, Germany
Volume :
403
Pages :
1395-1404
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The European Network Functional Advanced Materials and Engineering "FAME"
Available on ORBi :
since 15 May 2012

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