[en] The purpose of this retrospective study was to further identify in the equine species the clinical signs and blood parameters that could be useful to identify a hepatic disease and act as predictors of the outcome in animals suffering from an acute hepatic insufficiency. The study included 31 equids that were hospitalized at the University of Liege and that suffered from a hepatic (group 1, 17 cases of hepatitis; group 2, 11 cases of hyperlipemia) or post-hepatic (group 3, 3 cases of cholelithiasis) disease. Frequency of the clinical signs and values of selected blood parameters on admission were compared statistically between surviving and non-surviving animals. The most frequently presented clinical signs were depression, decreased appetite or anorexia, fever, tachycardia, polypnea, icterus, and congested mucous membranes. Frequency of the clinical signs and blood parameter values were not statistically different in surviving and non-surviving animals, with the exception of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP), which were significantly higher in animals with fatal outcome, with a cutoff value of 224 and 820 IU/L, respectively.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Amory, Hélène ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Perron, M. F.
Sandersen, Charlotte ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Delguste, C.
Grulke, Sigrid ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Morris DD, Henry MM. Hepatic encephalopathy. Comp Cont Ed Pract Vet. 13:1991;1153-1561
Milne EM. Differential diagnosis of hepatic disorders in horses. Practice. 12:1990;252-258
Barton MH, Morris DD. Diseases of the liver. Reed SM, Bayly WM. Equine internal medicine. 1998;707-738 W. B. Saunders Company, Philadelphia
Divers TJ. Hepatic disease. Robinson NE. Current therapy in equine medicine. 3rd ed.:1992;253-259 W. B. Saunders Company, Philadelphia
Divers TJ. Acute hepatic disease with failure. Mair T, Divers T, Ducharme N. Manual of equine gastroenterology. 2002;381-384 W. B. Saunders Company, Philadelphia
West HJ. Clinical and pathological studies in horses with hepatic disease. Equine Vet J. 28:1996;146-156
Ethell MT, Dart AJ, Hodgson DR, Rose RJ. Alimentary system. Rose RJ, Hodgson DR. Manual of equine practice. 2nd ed.:2000;273-339 W. B. Saunders Company, Philadelphia
Morris DD. Diseases of the hemolymphatic system. Reed SM, Bayly WM. Equine internal medicine. 1999;558-601 W. B. Saunders Company, Philadelphia
Traub-Dargatz JL. Biliary disorders. Robinson NE. Current therapy in equine medicine. 3rd ed.:1992;259-263 W. B. Saunders Company, Philadelphia
Durham AE, Newton JR, Smith KC, Hillyer LL, Smih MR, Marr CM. Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease. Equine Vet J. 35:(6):2003;542-547
Peek SF. Biliary tract disease. Mair T, Divers T. Manual of equine gastroenterology. 2002;386-389 W. B. Saunders Company, Philadelphia
Carlson GP. Pyrrolizidine alkaloid intoxication. Mair TM, Divers T, Ducharme N. Manual of equine gastroenterology. 2002;389-391 W. B. Saunders Company, Philadelphia
McGorum BC, Murphy D, Love S, Milne EM. Clinicopathological features of equine primary hepatic disease: a review of 50 cases. Vet Rec. 145:1999;134-139
Detilleux J, Arendt J, Lomba F, Leroy P. Methods for estimating areas under receiver-operating characteristic curves: illustration with somatic-cell scores in subclinical intramammary infections. Prev Vet Med. 41:1999;1975-1988
Greiner M, Pfeiffer D, Smith RD. Principles and application of the receiver-operating characteristics analysis for diagnostic tests. Prev Vet Med. 45:2000;23-41
Pearson EG. Liver failure attributable to pyrrolizidine alkaloid toxicosis and associated with inspiratory dyspnea in ponies: three cases (1982-1988). J Am Vet Med Assoc. 198:1991;1651-1654
Carlson GP. Chronic active hepatitis. Mair T, Divers T, Ducharme N. Manual of equine gastroenterology. 2002;391-392 W. B. Saunders Company, Philadelphia
Traub JL, Rantanen N, Reed S, Schecter L. Cholelithiasis in four horses. J Am Vet Med Assoc. 181:1982;159-162
Johnston JK, Divers TJ, Reef VB, Acland H. Cholelithiasis in horses: ten cases (1982-1986). J Am Vet Med Assoc. 194:1989;405-409
Grabner A. Case report. Cholangiopathy and cholelithiasis and acute hepatic syndrome. Tierarztl Prax. 25:1997;370-372
Peek SF, Divers TJ. Medical treatment of cholangiohepatitis and cholelithiasis in mature horses: 9 cases (1991-1998). Equine Vet J. 32:2000;301-306
Mair T. Hyperlipemia. Mair T, Divers T, Ducharme N. Manual of equine gastroenterology. 2002;394-402 W. B. Saunders Company, Philadelphia
Milne EM, Pogson DM, Doxey DL. Secondary gastric impaction associated with ragwort poisoning in three ponies. Vet Rec. 126:1990;502-504
Dixon PM, McGorum BC, Railton DI, Hawe C, Tremaire WH, Pickles K, et al. Laryngeal paralysis: a study of 375 cases in a mixed-breed population of horses. Equine Vet J. 33:2001;452-458
Parraga ME, Carlson GP, Thurmond M. Serum protein concentrations in horses with severe liver disease: a retrospective study and review of the literature. J Vet Int Med. 9:1995;154-161
Curran JM, Sutherland RJ, Peet RL. A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis. Aust Vet J. 74:1996;236-240
Tennant BC, Baldwin B, Evans CD, et al. Diseases of the equine liver. Proceedings of the American Association of Equine Practitioners; 1975;21:410-25.
Carlson GP. The liver. Mansmann RA, McAlister ES. Equine medicine and surgery. 3rd ed.:1982;633-639 American Veterinary Publications, Santa Barbara (Calif)
Johnston JK. Diseases of the liver. Colatan PJ, Mayhew IG, Merritt AM, Moore JN. Equine medicine and surgery. 4th ed.:1991;692-702 American Veterinary Publishers, Goleta (CA)
Durham AE, Smith KC, Newton JR, Hillyer MH, Hillyer LL, Smith MR, et al. Development and application of a scoring system for prognostic evaluation of equine liver biopsies. Equine Vet J. 35:(6):2003;534-540
Durham AE, Smith KC, Newton JR. An evaluation of diagnostic data in comparison to the results of liver biopsies in mature horses. Equine Vet J. 35:(6):2003;554-559
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