[en] Twenty healthy males were randomly divided into three groups. Each subject received either 405 mg elemental calcium (Ca) as a salt linked to an amino acid precursor, 405 mg CaC12 or 1000 mg Ca as Ca gluconolactate and carbonate. In all three cases, Ca intake led to an increase of serum Ca and TCT production and a decrease of PTH liberation. However, when Ca is linked to the amino acid precursor, an elective stimulation of growth hormone (GH) and somatomedin C (SmC) occurs. Due to the nature of its amino acid precursor, this salt seems to stimulate GH and SmC liberation through hypophysis. This could be a major pathway in decoupling of the sequence resorption-formation and therapy of metabolic bone diseases.
Disciplines :
Rheumatology
Author, co-author :
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Denis, D.
Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Lismonde, Stéphanie ; Centre Hospitalier Universitaire de Liège - CHU > Quartier accouchement NDB
Heynen, G.
Deroisy, Rita ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Franchimont, P.
Language :
English
Title :
Influence of the Nature of Calcium Salts on Serum Calcium, Phosphorus, Calcitonin, Growth Hormone, and Somatomedin C
Arnaud C.D., Goldsmith R.S., Bordier P.J., Sizemore G.W. (1971) Influence of immunoheterogeneity of circulating parathyroid hormone on results of radioimmunoassays of serum in man. Am J Med 56:785.
Arnaud C.D., Tsao H.S., Littledike T. (1971) Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest 50:21-34.
Canalis E. (1984) Local bone growth factors. Calc Tissue Int 36:632-634.
Franchimont P. Le dosages des hormones hypophysaires somatotrope et gonadotrope et son application clinique, Arscia, Bruxelles; 1967.
Franchimont P., Heynen G. Parathormone and calcitonin radioimmunoassay in various medical and osteoarticular disorders , Masson, New York Paris Barcelona Milan; 1976, 134.
Heynen G., Franchimont P. (1974) Human calcitonin radioimmunoassay in normal and pathological conditions. Eur J Clin Invest 4:213-222.
.
Merimee T.J., Rabinowitz D., Fineberg S.E. (1969) Arginine initiated release of human growth hormone. N Engl J Med 280:1434-1438.
Raisz L. (1984) Studies on bone formation and resorption in vitro. Hormone Res 20:22-27.
Rily M., Girard F., Bricaire H., Binoux M. (1982) The importance of insulin-like growth factor (somatomedin) measurements in diagnosis and surveillance of acromegaly. J Clin Endocrinol Metab 55:147.
Zapf J., Froesch E.R., Humbel R.E. (1981) The insulin-like growth factor (IGF) of human serum chimical and biological characterisation and aspects of their possible physiological role. Curr Top Cell Regul 19:257-309.
