Statistical analysis of serum protein electrophoresis results in External Quality Assessment schemes

[en] The goal of External Quality Assessment (EQA) schemes is to ensure that results obtained on a particular specimen in a given clinical laboratory are compatible with those obtained by other laboratories on the same specimen. Serum protein electrophoresis is a laboratory test consisting of five fractions (albumin, a1, a2, b and c globulins), which sum up to 100% of total proteins. So far, in EQA schemes the five fractions have been analyzed separately as for ordinary tests like glucose or cholesterol. This approach does not consider the fractions as a whole and the linear relationship between them. A statistical approach has been developed to analyze EQA electrophoresis results from a global standpoint by using robust multivariate method to eliminate the effect of outlying profiles. As illustrated on electrophoretic data from the Belgian EQA scheme, the novel approach improves the detection of poor performing laboratories. The method will be implemented in the Belgian EQA scheme on a routine basis.

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

Zhang, Lixin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Van Campenhout, Christel; Scientific Institute of Public Health > Department of Clinical Biology

Devleeschouwer, Nicole; Scientific Institute of Public Health > Department of Clinical Biology

Libeer, Jean-Claude; Scientific Institute of Public Health > Department of Clinical Biology

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Language :

English

Title :

Statistical analysis of serum protein electrophoresis results in External Quality Assessment schemes

Publication date :

March 2008

Journal title :

Accreditation and Quality Assurance

ISSN :

0949-1775

eISSN :

1432-0517

Publisher :

Springer, Berlin, Germany

Volume :

Issue :

Pages :

149-155

Peer reviewed :

Peer reviewed

Available on ORBi :

since 22 April 2009

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