Article (Scientific journals)
Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients.
Wang, François-Charles; De Pasqua, Victor; Gerard, Pascale et al.
2001In Neurology, 57 (5), p. 897-9
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Keywords :
Action Potentials/physiology; Adult; Aged; Amyotrophic Lateral Sclerosis/drug therapy/physiopathology; Humans; Median Nerve/physiology; Middle Aged; Muscular Atrophy/physiopathology; Neuroprotective Agents/therapeutic use; Prognosis; Prospective Studies; Riluzole/therapeutic use; Transcutaneous Electric Nerve Stimulation/methods
Abstract :
[en] Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year of riluzole therapy. The correlation between decrement and CMAP size reduction per year was highly significant (r = 0.77), but no relationship could be demonstrated between decrement and other variables. The authors thus propose that decrement after RNS may be used as a predictor of further drop in CMAP size.
Disciplines :
Neurology
Author, co-author :
Wang, François-Charles  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
De Pasqua, Victor ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Gerard, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Delwaide, Paul ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients.
Publication date :
2001
Journal title :
Neurology
ISSN :
0028-3878
eISSN :
1526-632X
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
57
Issue :
5
Pages :
897-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 April 2012

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