Article (Scientific journals)
Differential effects of testosterone on neuronal populations and their connections in a sensorimotor brain nucleus controlling song production in songbirds: a manganese enhanced-magnetic resonance imaging study
Van Meir, V.; Verhoye, M.; Absil, Philippe et al.
2004In NeuroImage, 21 (3), p. 914-923
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Keywords :
starling; songbird; song control nuclei; HVC; RA; area X; brain plasticity; testosterone; manganese enhanced-MRI
Abstract :
[en] Nucleus HVC (formerly called high vocal center) of songbirds contains two types of projecting neurons connecting HVC respectively to the nucleus robustus archistriatalis, RA, or to area X. These two neuron classes exhibit multiple neurochemical differences and are differentially replaced by new neurons during adult life: high rates of neuronal replacement are observed in RA-projecting neurons only. The activity of these two types of neurons may also be modulated differentially by steroids. We analyzed by magnetic resonance imaging the effect of testosterone on the volume of RA and area X and on the dynamics of Mn2+ accumulation in RA and area X of female starlings that had been injected with MnCl2 through a permanent cannula implanted in HVC. Repeated visualization 6 weeks apart (before and after testosterone treatment) identified a volume increase of both nuclei in testosterone-treated birds associated with a concomitant decrease in controls. Following testosterone treatment, the total amount of Mn2+ transported to RA and area X increased but the dynamics of accumulation, reflecting in part the activity of HVC neurons, was specifically altered in area X but not in RA. These data indicate that testosterone differentially affects the RA- and area X-projecting neurons in HVC. Manganese-enhanced magnetic resonance imaging (ME-MRI) thus provides repeated measures of connected brain areas and demonstrates testosterone-dependent regionally specific changes in brain activity and functional connectivity. The slow time scales investigated by this technique (compared to functional MRI) appear ideally suited for characterizing slow processes such as those involved in brain plasticity and learning. (C) 2004 Elsevier Inc. All rights reserved.
Disciplines :
Neurosciences & behavior
Radiology, nuclear medicine & imaging
Author, co-author :
Van Meir, V.
Verhoye, M.
Absil, Philippe ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Eens, M.
Balthazart, Jacques  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Van der Linden, A.
Language :
English
Title :
Differential effects of testosterone on neuronal populations and their connections in a sensorimotor brain nucleus controlling song production in songbirds: a manganese enhanced-magnetic resonance imaging study
Publication date :
March 2004
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Academic Press Inc Elsevier Science, San Diego, United States - California
Volume :
21
Issue :
3
Pages :
914-923
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 April 2009

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