Reference : Patterns of aluminum hydroxychloride deposition onto the skin.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/115640
Patterns of aluminum hydroxychloride deposition onto the skin.
English
Mayeux, Geraldine [Centre Hospitalier Universitaire de Liège - CHU > > > > Dermatopathologie > >]
Xhauflaire-Uhoda, Emmanuelle [Centre Hospitalier Universitaire de Liège - CHU > > > > Dermatopathologie > >]
PIERARD, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie]
2012
Skin Research and Technology
Blackwell Publishing
18
1
64-9
Yes (verified by ORBi)
International
0909-752X
1600-0846
Oxford
United Kingdom
[en] BACKGROUND: Aluminum hydroxychloride (AlCl(3) ) is an antiperspirant. AIM: To revisit the AlCl(3) deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS). METHODS: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl(3) on the forearms. The AlCl(3) -coated skin, glass slides and CSSS were observed using two ultraviolet light-emitting CCD cameras in order to record changes in specular reflectance related to AlCl(3) deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl(3) irritation. RESULTS: AlCl(3) deposited on glass slides looked as linear threads and rings of similar sizes. AlCl(3) deposits on skin were almost restricted inside the microrelief lines and as annular deposits at their crossings where acrosyringia are opening. After daily AlCl(3) applications, deposits extended on the CSSS plateaus. At rest in absence of sweating, TEWL was decreased following AlCl(3) applications. During physical exercise, the TEWL increase was limited on the AlCl(3) areas. CSSS appeared unreactive to AlCl(3) at the corneoxenometry bioassay. CONCLUSION: The similar aspect of AlCl(3) deposits on human SC and on glass slides suggested a physical property of AlCl(3) . Repetitive applications of AlCl(3) increased both the deposit area and the barrier function.
http://hdl.handle.net/2268/115640
10.1111/j.1600-0846.2011.00532.x
(c) 2011 John Wiley & Sons A/S.

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