Reference : Introduction a l'analyse spectrale des reseaux microvasculaires du melanome cutane pr...
Scientific journals : Article
Human health sciences : Dermatology
Introduction a l'analyse spectrale des reseaux microvasculaires du melanome cutane primitif.
[en] Spectral analysis of the microvasculature of primary cutaneous melanoma.
Quatresooz, Pascale mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques]
PIERARD, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie]
FRANCHIMONT, Claudine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Humbert, Philippe mailto [Hôpital Saint Jacques, Besançon, France > > > > Dermatologie > >]
Pierard, Sébastien mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Télécommunications]
Pathologie Biologie
Yes (verified by ORBi)
[en] Cutaneous malignant melanoma represents one of the most dramatic skin cancers because its incidence is steadily growing in White populations. Of note, its metastatic risk and mortality dramatically increase when the primary neoplasm reaches about one millimeter thick. It is believed that angiogenesis and lymphangiogenesis associated with cutaneous melanoma potentially influence the neoplastic progression of the primary tumor and its metastases. In some instances, both the intratumoral and peritumoral microvasculature are correlated to booming of the tumoral growth fraction. In addition, the vascular network serves as a migration path for the intravascular and perivascular neoplastic spread. Hence, the quantification of the microvasculature might help establishing a prognostic factor of evolution. Among the available methods, spectral analysis of immunohistochemical sections highlighting vessels helps defining the microvasculature distribution. The benefit of using spectral analysis is discussed and the modalities of application of this analytical method are scrutinized.
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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