Pharma clinics. Le médicament du mois. L'imiquimod (Aldara): un immunomodulateur pour la peau.

Adjuvants, Immunologic/pharmacology/therapeutic use; Aminoquinolines/pharmacology/therapeutic use; Cytokines/secretion; Humans; Macrophages/immunology; Skin Diseases/drug therapy/immunology

Abstract :

[en] Imiquimod is the first drug of a new therapeutic class encompassing cutaneous immune response modifiers. This molecule induces the synthesis and release of macrophage-related cytokines. It boosts some local immune responses. These properties are used to treat cutaneous viral condylomas. Other prospective therapeutic goals are presently scrutinized.

Disciplines :

Dermatology

Author, co-author :

Hermanns-Lê, Trinh ; Université de Liège - ULiège > Dermatopathologie

Nikkels, Arjen ; Université de Liège - ULiège > Dermatologie

Uhoda, Isabelle

Petit, L.

Pierard, Gérald ; Université de Liège - ULiège > Dermatopathologie

Language :

French

Title :

Pharma clinics. Le médicament du mois. L'imiquimod (Aldara): un immunomodulateur pour la peau.

Alternative titles :

[en] Pharma clinics. Medication of the month. Imiquimod (Aldara): an immunomodulator for the skin.

Publication date :

2002

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

116-8

Peer reviewed :

Peer reviewed

Available on ORBi :

since 20 April 2009

Statistics

Number of views

232 (4 by ULiège)

Number of downloads

482 (5 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenAlex citations

Bibliography

Beutner K.R., Spruance S.L., Hougham A.J. (1998) Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol 38:230-239.
Edwards L., Ferenczy A., Eron L. (1998) Self-administered topical 5% imiquimod cream for external anogenital warts. Arch Dermatol 134:25-30.
Tyring S.K., Arany I., Stanley M.A. (1998) A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod. J Infect Dis 178:551-555.
Bernstein D.I., Harrison C.J. (1998) Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus 2 infections. Antimicrob Agents Chemother 33:1511-1515.
Beutner K.R., Geisse J.K., Helman D. (1999) Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J Am Acad Dermatol 41:1002-1007.
Buckley R., Smith K. (1999) Topical imiquimod therapy for chronic giant molluscum contagiosum in a patient with advanced human immunodeficiency virus 1 disease. Arch Dermatol 135:1167-1169.
Arrese J.E., Paquet P., Claessens N. (2001) Dermal dendritic cells in anogenital warty lesions unresponsive to an immune-response modifier. J Cutan Pathol 28:131-134.
Testerman T.L., Gerster J.F., Imbertson L.M. (1995) Cytokine induction by the immunomodulators imiquimod and S-27609. J Leukoc Biol 58:365-372.
Imbertson L.M., Beaurline J.M., Couture A.M. (1998) Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol 110:734-739.
Slade H.B. (1998) Cytokine induction and modifying the immune response to human papilloma virus with imiquimod. Eur J Dermatol 8:13-16.
Miller R.L., Gerster J.F., Owens M.L. (1999) Imiquimod applied topically: A novel immune response modifier and new class of drug. Int J Immunopharmacol 21:1-14.
Stanley M.A. (1999) Mechanism of action of imiquimod. Papillomavirus Rep 10:23-29.
Hermanns-Lê T., Piérard G.E. Dermal monocytes and dendrocytes after prolonged imiquimod applications. Am J Dermatopathol, sous presse; .
Chen M., Griffith B.P., Lucia H.L. (1988) Efficacy of S-26308 against guinea pig cytomegalovirus. Antimicrob Agents Chemother 32:678-683.
Kende M., Lupton H.W., Canonico P.G. (1988) Treatment of experimental viral infections with immunomodulators. Adv Biosci 68:51.
Harrison C.J., Stanberry L.R., Bernstein D.I. (1991) Effects of cytokines and R-837, a cytokine inducer, on UV-irradiation augmented recurrent genital herpes in guinea pigs. Antiviral Res 15:315-322.
Sidky Y.A., Borden E.C., Weeks C.E. (1992) Inhibition of murine tumor growth by an interferon inducing imidazoquinolone. Cancer Res 52:3528-3533.
Burns Jr. R.P., Ferbel B., Tomai M. (2000) The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans' cells. Clin Immunol 94:13-23.
Gollnick H., Barasso R., Jappe U. (2001) Safety and efficacy of imiquimod 5% cream in the treatment of penile genital warts in uncircumcised men when applied three times weekly or once per day. Int J STD & AIDS 12:22-28.
Severson J., Evans T.Y., Lee P. (2001) Human papillomavirus infections: Epidemiology, pathogenesis, and therapy. J Cutan Med Surg 5:43-60.