Hearing Preservation in Cochlear Implantation and Drug Treatment.

[en] Insertion of an electrode array into the cochlea produces immediate damage to the inner ear, which is responsible for a hearing loss. In addition, a delayed hearing loss can be observed. In order to maximize hearing preservation after insertion of an electrode and to enhance the performance of the cochlear implant, it has been proposed to deliver pharmacological agents to the inner ear. Molecules can be administered locally to the inner ear through a direct perilymphatic perfusion or through the round window membrane. These modalities of treatment have already been successfully applied to some patients with inner ear diseases. In this paper, we will review some basic aspects of drug delivery to the inner ear to prevent the degeneration of the neurosensory hair cells and auditory neurons, and the actual applicability to humans in order to maintain hearing function after the insertion of electrodes of a cochlear implant.

Disciplines :

Otolaryngology
Neurology

Author, co-author :

Barriat, Sébastien ; Centre Hospitalier Universitaire de Liège - CHU > O.R.L.

Poirrier, Anne-Lise ; Centre Hospitalier Universitaire de Liège - CHU > O.R.L.

Malgrange, Brigitte ; Université de Liège - ULiège > GIGA - Neurosciences - Neurologie

Lefèbvre, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie

Language :

English

Title :

Hearing Preservation in Cochlear Implantation and Drug Treatment.

Publication date :

2010

Journal title :

Advances in Oto-Rhino-Laryngology

ISSN :

0065-3071

Publisher :

Karger, Basel, Switzerland

Volume :

Pages :

6-13

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 29 January 2010

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