[en] Dopamine (DA) is a powerful neuromodulator for a wide variety of behaviors. Considerable evidence accumulated from rodent and monkey experiments over the last two decades suggests that DA activity in the frontal cortex is reciprocally linked to that in functionally related basal ganglia (BG) structures. However, the functional importance of this in humans is still unknown. To address this issue, we measured endogenous DA release using positron emission tomography in 15 healthy subjects as they practiced the first training session of a finger sequence learning task. Significant results were observed not only in striatal areas but also in extrastriatal "motor" regions, bilaterally. Faster learning was specifically coupled to lower DA release in the sensorimotor part of the globus pallidus pars interna (GPi) contralateral to the moving hand, which was paralleled by a higher increase in DA levels in the pre-supplementary motor area (pre-SMA). This finding provides original evidence supporting a motor-learning-related interaction between DA release in left GPi and pre-SMA, a mechanism that may also apply to other anatomically and functionally interconnected BG and frontal cortical areas as a function of behavior.
Disciplines :
Neurosciences & behavior Radiology, nuclear medicine & imaging
Author, co-author :
Garraux, Gaëtan ; Université de Liège -& Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Peigneux, Philippe ; Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Carson, Richard E; Positron Emission Tomography Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Hallett, Mark; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Language :
English
Title :
Task-related interaction between basal ganglia and cortical dopamine release.
Publication date :
2007
Journal title :
Journal of Neuroscience
ISSN :
0270-6474
eISSN :
1529-2401
Publisher :
Society for Neuroscience, Washington, United States - District of Columbia
NINDS - National Institute of Neurological Disorders and Stroke [US-MD] [US-MD] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] BAEF - Belgian American Educational Foundation [BE] Fonds Léon Fredericq [BE] Horlait-Dapsens Foundations [BE]
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